Exploring the oncogenic and tumor-suppressive roles of Circ-ADAM9 in cancer

• Published in: Pathology, research and practice research and practice, 2024-04, Vol.256, p.155257-155257, Article 155257
• Main Authors: Hussain, Md Sadique, Moglad, Ehssan, Bansal, Pooja, Kaur, Harpreet, Deorari, Mahamedha, almalki, Waleed Hassan, Kazmi, Imran, Alzarea, Sami I., Singh, Mahaveer, Kukreti, Neelima
• Format: Article
• Language: English
• Subjects: Cancer; Circ-ADAM9; CircRNAs; MiRNA; Oncogene
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2024.155257

Circular RNAs (circRNAs) constitute a recently identified category of closed continuous loop RNA transcripts, serving as a subset of competing endogenous RNAs (ceRNAs) with the capacity to modulate genes by acting as microRNA sponges. In the context of cancer growth, numerous investigations have explored the potential functions of circRNAs, revealing their diverse functions either as oncogenes, promoting cancer progression, or as tumor suppressors, mitigating disease development. Among these, circRNA ADAM9 (Circ-ADAM9) is now recognized as an important player in a variety of mechanisms, both physiological and pathological, especially in cancer. The aberrant expression of Circ-ADAM9 has been observed across multiple human malignancies, implying a significant involvement in tumorigenesis. This comprehensive review aims to synthesize recent findings elucidating the function of Circ-ADAM9 in many malignancies. Additionally, the review explores the possibility of Circ-ADAM9 as a valuable biomarker, offering insights into its prognostic, diagnostic, and therapeutic implications. By summarizing the latest discoveries in this field, the review contributes to our understanding of the multifaceted contribution of Circ-ADAM9 in tumor biology and its potential applications in clinical settings.