Correlation of primary tumor volume and histopathologic response following neoadjuvant treatment of esophageal adenocarcinoma

In esophageal cancer, histopathologic response following neoadjuvant therapy and transthoracic esophagectomy is a strong predictor of long-term survival. At the present, it is not known whether the initial tumor volume quantified by computed tomography (CT) correlates with the degree of pathologic r...

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Bibliographic Details
Published in:European journal of surgical oncology 2024-04, Vol.50 (4), p.108003-108003, Article 108003
Main Authors: Bremm, Johannes, Brunner, Stefanie, Celik, Erkan, Damanakis, Alexander, Schlösser, Hans, Fuchs, Hans F., Schmidt, Thomas, Zander, Thomas, Maintz, David, Bruns, Christiane J., Quaas, Alexander, Pinto dos Santos, Daniel, Schroeder, Wolfgang
Format: Article
Language:English
Subjects:
Esophageal cancer
Esophagectomy
Neoadjuvant therapy
Tumor regression
Tumor volume
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Summary:In esophageal cancer, histopathologic response following neoadjuvant therapy and transthoracic esophagectomy is a strong predictor of long-term survival. At the present, it is not known whether the initial tumor volume quantified by computed tomography (CT) correlates with the degree of pathologic regression. In a retrospective analysis of a consecutive patient cohort with esophageal adenocarcinoma, tumor volume in CT prior to chemoradiotherapy or chemotherapy alone was quantified using manual segmentation. Primary tumor volume was correlated to the histomorphological regression based on vital residual tumor cells (VRTC) (Cologne regression scale, CRS: grade I, >50% VRTC; grade II, 10–50% VRTC; grade III,
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2024.108003