Potential contributions of keystone species to intestinal ecosystem in patients with Crohn's disease

Ravelling the central but poorly understood issue that potential contributions of keystone species to intestinal ecosystem functioning of patients with certain life-altering diseases including Crohn's disease (CD). In this study, a combination of 16S rRNA gene amplicon sequencing and amplicon-o...

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Bibliographic Details
Published in:Journal of applied microbiology 2024-04, Vol.135 (4)
Main Authors: Peng, Yuzhu, Zhao, Qi, Chen, Shuijiao, Li, Zhenyu, An, Di, Zhang, Xian
Format: Article
Language:English
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Summary:Ravelling the central but poorly understood issue that potential contributions of keystone species to intestinal ecosystem functioning of patients with certain life-altering diseases including Crohn's disease (CD). In this study, a combination of 16S rRNA gene amplicon sequencing and amplicon-oriented metagenomic profiling was applied to gain insights into the shifts in bacterial community composition at different stages of CD course, and explore the functional roles of identified keystone species in intestinal microecosystem. Our results showed significant alterations in structure and composition of gut microbiota between CD patients and healthy control (HC) (P 
ISSN:1365-2672
1365-2672
DOI:10.1093/jambio/lxae086