CRISPR-based identification of N-terminal acetylation in synucleinopathies

A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2024-05, Vol.47 (5), p.324-325
Main Authors: Bae, Eun-Jin, Lee, Seung-Jae
Format: Article
Language:English
Subjects:
Acetylation
alpha-Synuclein - genetics
alpha-Synuclein - metabolism
Animals
Clustered Regularly Interspaced Short Palindromic Repeats - genetics
Humans
NatB
Parkinson’s disease
proteasome
protein aggregation
Protein Processing, Post-Translational - physiology
Synucleinopathies - genetics
Synucleinopathies - metabolism
α-synuclein
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Summary:A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach. A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2024.03.006