Oral contraceptives in adolescents: a retrospective population-based study on blood pressure and metabolic dysregulation

Purpose This study aimed to explore the relationship between oral contraceptive use and blood pressure values and in a national cohort of women adolescents and to investigate the level of coexistence of the high blood pressure levels, dyslipidemia or insulin resistance. Methods This is a retrospecti...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2024-07, Vol.80 (7), p.1097-1103
Main Authors: de Araújo, Priscila Xavier, Moreira, Priscila, de Almeida, Danilo Candido, de Souza, Alexandra Aparecida, do Carmo Franco, Maria
Format: Article
Language:English
Subjects:
Adolescents
Biomedical and Life Sciences
Biomedicine
Birth control
Blood levels
Blood pressure
Cholesterol
Coexistence
Dyslipidemia
Hypertension
Insulin resistance
Metabolic disorders
Neural networks
Oral contraceptives
Pharmacists
Pharmacology/Toxicology
Population studies
Risk factors
Teenagers
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Summary:Purpose This study aimed to explore the relationship between oral contraceptive use and blood pressure values and in a national cohort of women adolescents and to investigate the level of coexistence of the high blood pressure levels, dyslipidemia or insulin resistance. Methods This is a retrospective cohort study that evaluated data form 14,299 adolescents aged 14 to 17 years. Crude and race-and age-adjusted analyses were performed using Poisson regression to estimate the prevalence ratios. Data clustering analysis was performed using machine learning approaches supported by an unsupervised neural network of self-organizing maps. Results We found that 14.5% ( n  = 2076) of the women adolescents use oral contraceptives. Moreover, an increased prevalence of high blood pressure, dyslipidemia, and insulin resistance (all P  
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-024-03671-z