PD-L1 expression in head and neck squamous cell carcinoma and its clinical significance: A prospective observational study from a tertiary care centre

Programmed Death Ligand 1 (PD-L1) expression in tumor cells contribute to tumor immunity and therapies directed against it, have shown encouraging results in recent years. As there is limited data on the significance of PD-L1 expression in Head and Neck Squamous Cell Carcinoma (HNSCC) from India, we...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and therapeutics 2024-01, Vol.20 (1), p.46-51
Main Authors: Kilaru, Sindhu, Panda, Soumya Surath, Moharana, Lalatendu, Mohapatra, Debahuti, Mohapatra, Satya Sundar G, Panda, Adyakinkar, Kolluri, Spoorthy, Devaraj, Suma, Kabi, Ananya, Das, Bharat, Biswas, Ghanashyam
Format: Article
Language:English
Subjects:
Adult
Apoptosis
B7-H1 Antigen
Biomarkers, Tumor - metabolism
Care and treatment
Diagnosis
Female
Head & neck cancer
Head and neck cancer
Head and Neck Neoplasms
Health aspects
Humans
Male
Measurement
Membrane proteins
Middle Aged
Patient outcomes
Prognosis
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Tertiary Care Centers
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Programmed Death Ligand 1 (PD-L1) expression in tumor cells contribute to tumor immunity and therapies directed against it, have shown encouraging results in recent years. As there is limited data on the significance of PD-L1 expression in Head and Neck Squamous Cell Carcinoma (HNSCC) from India, we aimed to study the PD-L1 expression and its relation with different clinic-pathological parameters in patients of HNSCC from a tertiary care center in Eastern India. A prospective evaluation of HNSCC patients diagnosed and managed at our center over a period of two and half years, was performed. PD-L1 expression in formalin fixed-paraffin embedded tumor tissue specimens was measured using SP-263 (Ventana) and 22C3 (Dako). A PD-L1 expression of
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.jcrt_1239_22