The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose-response meta-analysis of randomized clinical trials

The present systematic review and dose-response meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of citrus flavonoids supplementation (CFS) on endothelial function. Relevant RCTs were identified through comprehensive searches of the...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2024-06, Vol.38 (6), p.2847-2859
Main Authors: Jalili, Farnaz, Moradi, Sajjad, Talebi, Sepide, Mehrabani, Sanaz, Ghoreishy, Seyed Mojtaba, Wong, Alexei, Jalalvand, Ali R, Kermani, Mohammad Ali Hojjati, Jalili, Cyrus, Jalili, Faramarz
Format: Article
Language:English
Subjects:
Citrus - chemistry
Clinical trials
Dietary Supplements
Dose-Response Relationship, Drug
Endothelium, Vascular - drug effects
Flavonoids
Flavonoids - pharmacology
Humans
Linearity
Meta-analysis
Nonlinear response
Randomized Controlled Trials as Topic
Statistical analysis
Systematic review
Vasodilation
Vasodilation - drug effects
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present systematic review and dose-response meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of citrus flavonoids supplementation (CFS) on endothelial function. Relevant RCTs were identified through comprehensive searches of the PubMed, ISI Web of Science, and Scopus databases up to May 30, 2023. Weighted mean differences and their corresponding 95% confidence intervals (CI) were pooled utilizing a random-effects model. A total of eight eligible RCTs, comprising 596 participants, were included in the analysis. The pooled data demonstrated a statistically significant augmentation in flow-mediated vasodilation (FMD) (2.75%; 95% CI: 1.29, 4.20; I  = 87.3%; p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.8190