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Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe
To evaluate the association between raphe in bicuspid aortic valve (BAV) patients and valve dysfunction, aortopathy and aortic valve surgery in the REBECCA registry [REgistro della valvola aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging (SIECVI)]. Prevalence of a...
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| Published in: | International journal of cardiology 2024-07, Vol.407, p.132000-132000, Article 132000 |
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| container_end_page | 132000 |
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| container_title | International journal of cardiology |
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| creator | Bellino, Michele Antonini-Canterin, Francesco Bossone, Eduardo Faggiano, Pompilio Chirillo, Fabio La Carrubba, Salvatore Faganello, Giorgio Cecconi, Moreno Zito, Concetta Dasseni, Nicolò Nistri, Stefano Moreo, Antonella Fabiani, Iacopo Faden, Giacomo Agostini, Francesco Manuppelli, Vincenzo Cameli, Matteo Cresti, Alberto Dentamaro, Ilaria Monte, Ines Paola Barbieri, Andrea Ciampi, Quirino Giorgi, Mauro Galasso, Gennaro Carerj, Scipione Pepi, Mauro Benedetto, Frank Colonna, Paolo Citro, Rodolfo |
| description | To evaluate the association between raphe in bicuspid aortic valve (BAV) patients and valve dysfunction, aortopathy and aortic valve surgery in the REBECCA registry [REgistro della valvola aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging (SIECVI)].
Prevalence of aortic valve dysfunction and aortopathy was investigated in BAV patients with and without raphe. Aortic valve dysfunction (regurgitation or stenosis) was categorized as mild, moderate and severe. Aortopathy was defined as annulus ≥14 mm/m2; root ≥20 mm/m2; sinotubular junction ≥16 mm/m2; ascending aorta ≥17 mm/m2, and classified in Type A, isolated ascending aorta dilatation; Type B, aortic root and ascending aorta dilatation; and Type C, isolated aortic root dilatation.
Overall, 695 patients with BAV were enrolled; 520 (74.8%) with raphe and 175 (25.2%) without raphe. BAV patients with raphe presented more frequently with moderate or severe aortic stenosis than BAV patients without raphe (183 [35.2%] vs 34 [19.4%], p |
| doi_str_mv | 10.1016/j.ijcard.2024.132000 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3031132310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527324005503</els_id><sourcerecordid>3031132310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-1231c5a2766898cd76f0bbbe73cb6a7638ea4dd79ccb3543ea0608f803d48ba13</originalsourceid><addsrcrecordid>eNp9kEtPwzAMgCMEYmPwDxDKkUtH0rRJdkGaJl7SJC5wjvLwWKauLUk7tH9PRoEDB0625c-2_CF0ScmUEspvNlO_sTq4aU7yYkpZTgg5QmMqRZFRURbHaJwwkZW5YCN0FuMmAcVsJk_RiMmSU0rkGOl5E7qm1d16j3XtsE6lt3inqx3g2Ic3CHvsa5wID3UX8Yfv1th428fW_8G_Woclh6TpOxx0u4ZzdLLSVYSL7zhBr_d3L4vHbPn88LSYLzPLeN5lNGfUljoXnMuZtE7wFTHGgGDWcC04k6AL58TMWsPKgoEmnMiVJMwV0mjKJuh62NuG5r2H2KmtjxaqStfQ9FExwmiyxChJaDGgNjQxBlipNvitDntFiTrIVRs1yFUHuWqQm8auvi_0Zgvud-jHZgJuBwDSnzsPQUWbrFlwPoDtlGv8_xc-AZTJjZc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3031132310</pqid></control><display><type>article</type><title>Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Bellino, Michele ; Antonini-Canterin, Francesco ; Bossone, Eduardo ; Faggiano, Pompilio ; Chirillo, Fabio ; La Carrubba, Salvatore ; Faganello, Giorgio ; Cecconi, Moreno ; Zito, Concetta ; Dasseni, Nicolò ; Nistri, Stefano ; Moreo, Antonella ; Fabiani, Iacopo ; Faden, Giacomo ; Agostini, Francesco ; Manuppelli, Vincenzo ; Cameli, Matteo ; Cresti, Alberto ; Dentamaro, Ilaria ; Monte, Ines Paola ; Barbieri, Andrea ; Ciampi, Quirino ; Giorgi, Mauro ; Galasso, Gennaro ; Carerj, Scipione ; Pepi, Mauro ; Benedetto, Frank ; Colonna, Paolo ; Citro, Rodolfo</creator><creatorcontrib>Bellino, Michele ; Antonini-Canterin, Francesco ; Bossone, Eduardo ; Faggiano, Pompilio ; Chirillo, Fabio ; La Carrubba, Salvatore ; Faganello, Giorgio ; Cecconi, Moreno ; Zito, Concetta ; Dasseni, Nicolò ; Nistri, Stefano ; Moreo, Antonella ; Fabiani, Iacopo ; Faden, Giacomo ; Agostini, Francesco ; Manuppelli, Vincenzo ; Cameli, Matteo ; Cresti, Alberto ; Dentamaro, Ilaria ; Monte, Ines Paola ; Barbieri, Andrea ; Ciampi, Quirino ; Giorgi, Mauro ; Galasso, Gennaro ; Carerj, Scipione ; Pepi, Mauro ; Benedetto, Frank ; Colonna, Paolo ; Citro, Rodolfo</creatorcontrib><description>To evaluate the association between raphe in bicuspid aortic valve (BAV) patients and valve dysfunction, aortopathy and aortic valve surgery in the REBECCA registry [REgistro della valvola aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging (SIECVI)].
Prevalence of aortic valve dysfunction and aortopathy was investigated in BAV patients with and without raphe. Aortic valve dysfunction (regurgitation or stenosis) was categorized as mild, moderate and severe. Aortopathy was defined as annulus ≥14 mm/m2; root ≥20 mm/m2; sinotubular junction ≥16 mm/m2; ascending aorta ≥17 mm/m2, and classified in Type A, isolated ascending aorta dilatation; Type B, aortic root and ascending aorta dilatation; and Type C, isolated aortic root dilatation.
Overall, 695 patients with BAV were enrolled; 520 (74.8%) with raphe and 175 (25.2%) without raphe. BAV patients with raphe presented more frequently with moderate or severe aortic stenosis than BAV patients without raphe (183 [35.2%] vs 34 [19.4%], p < 0.001). A higher prevalence of aortopathy, particularly Type B, was observed in patients with vs without raphe. At multivariable analysis, raphe was a predictor of aortic valve surgery at three-year follow-up (odds ratio 2.19, 95% confidence interval 1.08–4.44, p < 0.001).
Patients with BAV and raphe have a higher prevalence of significant aortic stenosis, aortopathy, especially Type B, and a higher risk of undergoing aortic valve surgery at three-year follow-up.
Study design of the REBECCA registry and main study findings. [Display omitted]
•Our study shows most importantly that patients with BAV and raphe have:•Increased risk of significant aortic valve stenosis,•Lower values of LV GLS,•Higher frequency of aortopathy, especially type B, accordingly to Michelena's classification,•Higher probability to undergo to aortic valve surgery at three-year follow-up. (Central figure).</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2024.132000</identifier><identifier>PMID: 38561108</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aortic Diseases - diagnostic imaging ; Aortic Diseases - epidemiology ; Aortic Diseases - surgery ; Aortic Valve - abnormalities ; Aortic Valve - diagnostic imaging ; Aortic Valve - surgery ; Aortic Valve Stenosis - diagnostic imaging ; Aortic Valve Stenosis - surgery ; Aortopathy ; Bicuspid aortic valve ; Bicuspid Aortic Valve Disease - complications ; Bicuspid Aortic Valve Disease - diagnostic imaging ; Bicuspid Aortic Valve Disease - surgery ; Female ; Follow-Up Studies ; Heart Valve Diseases - complications ; Heart Valve Diseases - diagnostic imaging ; Heart Valve Diseases - surgery ; Humans ; Italy - epidemiology ; Male ; Middle Aged ; Registries ; Valvulopathy</subject><ispartof>International journal of cardiology, 2024-07, Vol.407, p.132000-132000, Article 132000</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-1231c5a2766898cd76f0bbbe73cb6a7638ea4dd79ccb3543ea0608f803d48ba13</citedby><cites>FETCH-LOGICAL-c362t-1231c5a2766898cd76f0bbbe73cb6a7638ea4dd79ccb3543ea0608f803d48ba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38561108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellino, Michele</creatorcontrib><creatorcontrib>Antonini-Canterin, Francesco</creatorcontrib><creatorcontrib>Bossone, Eduardo</creatorcontrib><creatorcontrib>Faggiano, Pompilio</creatorcontrib><creatorcontrib>Chirillo, Fabio</creatorcontrib><creatorcontrib>La Carrubba, Salvatore</creatorcontrib><creatorcontrib>Faganello, Giorgio</creatorcontrib><creatorcontrib>Cecconi, Moreno</creatorcontrib><creatorcontrib>Zito, Concetta</creatorcontrib><creatorcontrib>Dasseni, Nicolò</creatorcontrib><creatorcontrib>Nistri, Stefano</creatorcontrib><creatorcontrib>Moreo, Antonella</creatorcontrib><creatorcontrib>Fabiani, Iacopo</creatorcontrib><creatorcontrib>Faden, Giacomo</creatorcontrib><creatorcontrib>Agostini, Francesco</creatorcontrib><creatorcontrib>Manuppelli, Vincenzo</creatorcontrib><creatorcontrib>Cameli, Matteo</creatorcontrib><creatorcontrib>Cresti, Alberto</creatorcontrib><creatorcontrib>Dentamaro, Ilaria</creatorcontrib><creatorcontrib>Monte, Ines Paola</creatorcontrib><creatorcontrib>Barbieri, Andrea</creatorcontrib><creatorcontrib>Ciampi, Quirino</creatorcontrib><creatorcontrib>Giorgi, Mauro</creatorcontrib><creatorcontrib>Galasso, Gennaro</creatorcontrib><creatorcontrib>Carerj, Scipione</creatorcontrib><creatorcontrib>Pepi, Mauro</creatorcontrib><creatorcontrib>Benedetto, Frank</creatorcontrib><creatorcontrib>Colonna, Paolo</creatorcontrib><creatorcontrib>Citro, Rodolfo</creatorcontrib><title>Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>To evaluate the association between raphe in bicuspid aortic valve (BAV) patients and valve dysfunction, aortopathy and aortic valve surgery in the REBECCA registry [REgistro della valvola aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging (SIECVI)].
Prevalence of aortic valve dysfunction and aortopathy was investigated in BAV patients with and without raphe. Aortic valve dysfunction (regurgitation or stenosis) was categorized as mild, moderate and severe. Aortopathy was defined as annulus ≥14 mm/m2; root ≥20 mm/m2; sinotubular junction ≥16 mm/m2; ascending aorta ≥17 mm/m2, and classified in Type A, isolated ascending aorta dilatation; Type B, aortic root and ascending aorta dilatation; and Type C, isolated aortic root dilatation.
Overall, 695 patients with BAV were enrolled; 520 (74.8%) with raphe and 175 (25.2%) without raphe. BAV patients with raphe presented more frequently with moderate or severe aortic stenosis than BAV patients without raphe (183 [35.2%] vs 34 [19.4%], p < 0.001). A higher prevalence of aortopathy, particularly Type B, was observed in patients with vs without raphe. At multivariable analysis, raphe was a predictor of aortic valve surgery at three-year follow-up (odds ratio 2.19, 95% confidence interval 1.08–4.44, p < 0.001).
Patients with BAV and raphe have a higher prevalence of significant aortic stenosis, aortopathy, especially Type B, and a higher risk of undergoing aortic valve surgery at three-year follow-up.
Study design of the REBECCA registry and main study findings. [Display omitted]
•Our study shows most importantly that patients with BAV and raphe have:•Increased risk of significant aortic valve stenosis,•Lower values of LV GLS,•Higher frequency of aortopathy, especially type B, accordingly to Michelena's classification,•Higher probability to undergo to aortic valve surgery at three-year follow-up. (Central figure).</description><subject>Adult</subject><subject>Aged</subject><subject>Aortic Diseases - diagnostic imaging</subject><subject>Aortic Diseases - epidemiology</subject><subject>Aortic Diseases - surgery</subject><subject>Aortic Valve - abnormalities</subject><subject>Aortic Valve - diagnostic imaging</subject><subject>Aortic Valve - surgery</subject><subject>Aortic Valve Stenosis - diagnostic imaging</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Aortopathy</subject><subject>Bicuspid aortic valve</subject><subject>Bicuspid Aortic Valve Disease - complications</subject><subject>Bicuspid Aortic Valve Disease - diagnostic imaging</subject><subject>Bicuspid Aortic Valve Disease - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Valve Diseases - complications</subject><subject>Heart Valve Diseases - diagnostic imaging</subject><subject>Heart Valve Diseases - surgery</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Registries</subject><subject>Valvulopathy</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAMgCMEYmPwDxDKkUtH0rRJdkGaJl7SJC5wjvLwWKauLUk7tH9PRoEDB0625c-2_CF0ScmUEspvNlO_sTq4aU7yYkpZTgg5QmMqRZFRURbHaJwwkZW5YCN0FuMmAcVsJk_RiMmSU0rkGOl5E7qm1d16j3XtsE6lt3inqx3g2Ic3CHvsa5wID3UX8Yfv1th428fW_8G_Woclh6TpOxx0u4ZzdLLSVYSL7zhBr_d3L4vHbPn88LSYLzPLeN5lNGfUljoXnMuZtE7wFTHGgGDWcC04k6AL58TMWsPKgoEmnMiVJMwV0mjKJuh62NuG5r2H2KmtjxaqStfQ9FExwmiyxChJaDGgNjQxBlipNvitDntFiTrIVRs1yFUHuWqQm8auvi_0Zgvud-jHZgJuBwDSnzsPQUWbrFlwPoDtlGv8_xc-AZTJjZc</recordid><startdate>20240715</startdate><enddate>20240715</enddate><creator>Bellino, Michele</creator><creator>Antonini-Canterin, Francesco</creator><creator>Bossone, Eduardo</creator><creator>Faggiano, Pompilio</creator><creator>Chirillo, Fabio</creator><creator>La Carrubba, Salvatore</creator><creator>Faganello, Giorgio</creator><creator>Cecconi, Moreno</creator><creator>Zito, Concetta</creator><creator>Dasseni, Nicolò</creator><creator>Nistri, Stefano</creator><creator>Moreo, Antonella</creator><creator>Fabiani, Iacopo</creator><creator>Faden, Giacomo</creator><creator>Agostini, Francesco</creator><creator>Manuppelli, Vincenzo</creator><creator>Cameli, Matteo</creator><creator>Cresti, Alberto</creator><creator>Dentamaro, Ilaria</creator><creator>Monte, Ines Paola</creator><creator>Barbieri, Andrea</creator><creator>Ciampi, Quirino</creator><creator>Giorgi, Mauro</creator><creator>Galasso, Gennaro</creator><creator>Carerj, Scipione</creator><creator>Pepi, Mauro</creator><creator>Benedetto, Frank</creator><creator>Colonna, Paolo</creator><creator>Citro, Rodolfo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240715</creationdate><title>Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe</title><author>Bellino, Michele ; Antonini-Canterin, Francesco ; Bossone, Eduardo ; Faggiano, Pompilio ; Chirillo, Fabio ; La Carrubba, Salvatore ; Faganello, Giorgio ; Cecconi, Moreno ; Zito, Concetta ; Dasseni, Nicolò ; Nistri, Stefano ; Moreo, Antonella ; Fabiani, Iacopo ; Faden, Giacomo ; Agostini, Francesco ; Manuppelli, Vincenzo ; Cameli, Matteo ; Cresti, Alberto ; Dentamaro, Ilaria ; Monte, Ines Paola ; Barbieri, Andrea ; Ciampi, Quirino ; Giorgi, Mauro ; Galasso, Gennaro ; Carerj, Scipione ; Pepi, Mauro ; Benedetto, Frank ; Colonna, Paolo ; Citro, Rodolfo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-1231c5a2766898cd76f0bbbe73cb6a7638ea4dd79ccb3543ea0608f803d48ba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aortic Diseases - diagnostic imaging</topic><topic>Aortic Diseases - epidemiology</topic><topic>Aortic Diseases - surgery</topic><topic>Aortic Valve - abnormalities</topic><topic>Aortic Valve - diagnostic imaging</topic><topic>Aortic Valve - surgery</topic><topic>Aortic Valve Stenosis - diagnostic imaging</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Aortopathy</topic><topic>Bicuspid aortic valve</topic><topic>Bicuspid Aortic Valve Disease - complications</topic><topic>Bicuspid Aortic Valve Disease - diagnostic imaging</topic><topic>Bicuspid Aortic Valve Disease - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Valve Diseases - complications</topic><topic>Heart Valve Diseases - diagnostic imaging</topic><topic>Heart Valve Diseases - surgery</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Registries</topic><topic>Valvulopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellino, Michele</creatorcontrib><creatorcontrib>Antonini-Canterin, Francesco</creatorcontrib><creatorcontrib>Bossone, Eduardo</creatorcontrib><creatorcontrib>Faggiano, Pompilio</creatorcontrib><creatorcontrib>Chirillo, Fabio</creatorcontrib><creatorcontrib>La Carrubba, Salvatore</creatorcontrib><creatorcontrib>Faganello, Giorgio</creatorcontrib><creatorcontrib>Cecconi, Moreno</creatorcontrib><creatorcontrib>Zito, Concetta</creatorcontrib><creatorcontrib>Dasseni, Nicolò</creatorcontrib><creatorcontrib>Nistri, Stefano</creatorcontrib><creatorcontrib>Moreo, Antonella</creatorcontrib><creatorcontrib>Fabiani, Iacopo</creatorcontrib><creatorcontrib>Faden, Giacomo</creatorcontrib><creatorcontrib>Agostini, Francesco</creatorcontrib><creatorcontrib>Manuppelli, Vincenzo</creatorcontrib><creatorcontrib>Cameli, Matteo</creatorcontrib><creatorcontrib>Cresti, Alberto</creatorcontrib><creatorcontrib>Dentamaro, Ilaria</creatorcontrib><creatorcontrib>Monte, Ines Paola</creatorcontrib><creatorcontrib>Barbieri, Andrea</creatorcontrib><creatorcontrib>Ciampi, Quirino</creatorcontrib><creatorcontrib>Giorgi, Mauro</creatorcontrib><creatorcontrib>Galasso, Gennaro</creatorcontrib><creatorcontrib>Carerj, Scipione</creatorcontrib><creatorcontrib>Pepi, Mauro</creatorcontrib><creatorcontrib>Benedetto, Frank</creatorcontrib><creatorcontrib>Colonna, Paolo</creatorcontrib><creatorcontrib>Citro, Rodolfo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellino, Michele</au><au>Antonini-Canterin, Francesco</au><au>Bossone, Eduardo</au><au>Faggiano, Pompilio</au><au>Chirillo, Fabio</au><au>La Carrubba, Salvatore</au><au>Faganello, Giorgio</au><au>Cecconi, Moreno</au><au>Zito, Concetta</au><au>Dasseni, Nicolò</au><au>Nistri, Stefano</au><au>Moreo, Antonella</au><au>Fabiani, Iacopo</au><au>Faden, Giacomo</au><au>Agostini, Francesco</au><au>Manuppelli, Vincenzo</au><au>Cameli, Matteo</au><au>Cresti, Alberto</au><au>Dentamaro, Ilaria</au><au>Monte, Ines Paola</au><au>Barbieri, Andrea</au><au>Ciampi, Quirino</au><au>Giorgi, Mauro</au><au>Galasso, Gennaro</au><au>Carerj, Scipione</au><au>Pepi, Mauro</au><au>Benedetto, Frank</au><au>Colonna, Paolo</au><au>Citro, Rodolfo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2024-07-15</date><risdate>2024</risdate><volume>407</volume><spage>132000</spage><epage>132000</epage><pages>132000-132000</pages><artnum>132000</artnum><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>To evaluate the association between raphe in bicuspid aortic valve (BAV) patients and valve dysfunction, aortopathy and aortic valve surgery in the REBECCA registry [REgistro della valvola aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging (SIECVI)].
Prevalence of aortic valve dysfunction and aortopathy was investigated in BAV patients with and without raphe. Aortic valve dysfunction (regurgitation or stenosis) was categorized as mild, moderate and severe. Aortopathy was defined as annulus ≥14 mm/m2; root ≥20 mm/m2; sinotubular junction ≥16 mm/m2; ascending aorta ≥17 mm/m2, and classified in Type A, isolated ascending aorta dilatation; Type B, aortic root and ascending aorta dilatation; and Type C, isolated aortic root dilatation.
Overall, 695 patients with BAV were enrolled; 520 (74.8%) with raphe and 175 (25.2%) without raphe. BAV patients with raphe presented more frequently with moderate or severe aortic stenosis than BAV patients without raphe (183 [35.2%] vs 34 [19.4%], p < 0.001). A higher prevalence of aortopathy, particularly Type B, was observed in patients with vs without raphe. At multivariable analysis, raphe was a predictor of aortic valve surgery at three-year follow-up (odds ratio 2.19, 95% confidence interval 1.08–4.44, p < 0.001).
Patients with BAV and raphe have a higher prevalence of significant aortic stenosis, aortopathy, especially Type B, and a higher risk of undergoing aortic valve surgery at three-year follow-up.
Study design of the REBECCA registry and main study findings. [Display omitted]
•Our study shows most importantly that patients with BAV and raphe have:•Increased risk of significant aortic valve stenosis,•Lower values of LV GLS,•Higher frequency of aortopathy, especially type B, accordingly to Michelena's classification,•Higher probability to undergo to aortic valve surgery at three-year follow-up. (Central figure).</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38561108</pmid><doi>10.1016/j.ijcard.2024.132000</doi><tpages>1</tpages></addata></record> |
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| ispartof | International journal of cardiology, 2024-07, Vol.407, p.132000-132000, Article 132000 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adult Aged Aortic Diseases - diagnostic imaging Aortic Diseases - epidemiology Aortic Diseases - surgery Aortic Valve - abnormalities Aortic Valve - diagnostic imaging Aortic Valve - surgery Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - surgery Aortopathy Bicuspid aortic valve Bicuspid Aortic Valve Disease - complications Bicuspid Aortic Valve Disease - diagnostic imaging Bicuspid Aortic Valve Disease - surgery Female Follow-Up Studies Heart Valve Diseases - complications Heart Valve Diseases - diagnostic imaging Heart Valve Diseases - surgery Humans Italy - epidemiology Male Middle Aged Registries Valvulopathy |
| title | Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe |
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