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How Does Ultrasound Global OMERACT–EULAR Synovitis Score (GLOESS) for Rheumatoid Arthritis (RA) Activity Assessment Perform in Real‐Life?
Objective This study aimed to assess the effectiveness of the Global OMERACT–EULAR Synovitis Score (GLOESS) of bilateral second to fifth metacarpophalangeal joints (MCP 2–5) in evaluating rheumatoid arthritis (RA) activity in a real‐life setting. Methods This cross‐sectional study included consecuti...
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| Published in: | Journal of ultrasound in medicine 2024-07, Vol.43 (7), p.1313-1318 |
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| container_end_page | 1318 |
| container_issue | 7 |
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| container_title | Journal of ultrasound in medicine |
| container_volume | 43 |
| creator | Andrade, Nicole Pamplona Bueno Brenol, Claiton Viegas Silva Chakr, Rafael Mendonça |
| description | Objective
This study aimed to assess the effectiveness of the Global OMERACT–EULAR Synovitis Score (GLOESS) of bilateral second to fifth metacarpophalangeal joints (MCP 2–5) in evaluating rheumatoid arthritis (RA) activity in a real‐life setting.
Methods
This cross‐sectional study included consecutive RA patients without hyperalgesia. Clinical data were extracted from electronic medical records. Evaluations were conducted on bilateral MCP 2–5 by two independent experts in musculoskeletal ultrasound (MSUS). Correlation between clinical and ultrasonographic parameters was analyzed, aiming to define a cutoff value for detecting disease activity.
Results
Sixty‐nine patients were included. The mean DAS28‐ESR was 4.3 (±1.4), and the median GLOESS was 7 (13). The correlation between GLOESS and DAS28 was moderate (r = .62; P |
| doi_str_mv | 10.1002/jum.16455 |
| format | article |
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This study aimed to assess the effectiveness of the Global OMERACT–EULAR Synovitis Score (GLOESS) of bilateral second to fifth metacarpophalangeal joints (MCP 2–5) in evaluating rheumatoid arthritis (RA) activity in a real‐life setting.
Methods
This cross‐sectional study included consecutive RA patients without hyperalgesia. Clinical data were extracted from electronic medical records. Evaluations were conducted on bilateral MCP 2–5 by two independent experts in musculoskeletal ultrasound (MSUS). Correlation between clinical and ultrasonographic parameters was analyzed, aiming to define a cutoff value for detecting disease activity.
Results
Sixty‐nine patients were included. The mean DAS28‐ESR was 4.3 (±1.4), and the median GLOESS was 7 (13). The correlation between GLOESS and DAS28 was moderate (r = .62; P < .05). A total GLOESS score of ≤3 and all joints with both GS and PD ≤1 showed good sensitivity and specificity for detecting disease activity (remission/low vs moderate/high, P = 0).
Conclusion
In a real‐life scenario, GLOESS for MCP 2–5 emerges as a valuable measure of RA activity. The optimal cutoff distinguishing remission/low from moderate/high disease activity was determined to be GLOESS ≤3, with all MCP joints exhibiting both GS and PD scores of ≤1.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.1002/jum.16455</identifier><identifier>PMID: 38558471</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - diagnostic imaging ; Cross-Sectional Studies ; Female ; GLOESS ; Humans ; Male ; Metacarpophalangeal Joint - diagnostic imaging ; Middle Aged ; Reproducibility of Results ; rheumatoid arthritis ; Sensitivity and Specificity ; Severity of Illness Index ; synovitis ; Synovitis - diagnostic imaging ; Ultrasonography - methods ; ultrasound</subject><ispartof>Journal of ultrasound in medicine, 2024-07, Vol.43 (7), p.1313-1318</ispartof><rights>2024 American Institute of Ultrasound in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2855-b25935c2cacce453f1998119f48d10cc155027fc8e18ccf58e60decb621769c53</cites><orcidid>0000-0003-1090-3708</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38558471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrade, Nicole Pamplona Bueno</creatorcontrib><creatorcontrib>Brenol, Claiton Viegas</creatorcontrib><creatorcontrib>Silva Chakr, Rafael Mendonça</creatorcontrib><title>How Does Ultrasound Global OMERACT–EULAR Synovitis Score (GLOESS) for Rheumatoid Arthritis (RA) Activity Assessment Perform in Real‐Life?</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>Objective
This study aimed to assess the effectiveness of the Global OMERACT–EULAR Synovitis Score (GLOESS) of bilateral second to fifth metacarpophalangeal joints (MCP 2–5) in evaluating rheumatoid arthritis (RA) activity in a real‐life setting.
Methods
This cross‐sectional study included consecutive RA patients without hyperalgesia. Clinical data were extracted from electronic medical records. Evaluations were conducted on bilateral MCP 2–5 by two independent experts in musculoskeletal ultrasound (MSUS). Correlation between clinical and ultrasonographic parameters was analyzed, aiming to define a cutoff value for detecting disease activity.
Results
Sixty‐nine patients were included. The mean DAS28‐ESR was 4.3 (±1.4), and the median GLOESS was 7 (13). The correlation between GLOESS and DAS28 was moderate (r = .62; P < .05). A total GLOESS score of ≤3 and all joints with both GS and PD ≤1 showed good sensitivity and specificity for detecting disease activity (remission/low vs moderate/high, P = 0).
Conclusion
In a real‐life scenario, GLOESS for MCP 2–5 emerges as a valuable measure of RA activity. The optimal cutoff distinguishing remission/low from moderate/high disease activity was determined to be GLOESS ≤3, with all MCP joints exhibiting both GS and PD scores of ≤1.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>GLOESS</subject><subject>Humans</subject><subject>Male</subject><subject>Metacarpophalangeal Joint - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Reproducibility of Results</subject><subject>rheumatoid arthritis</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>synovitis</subject><subject>Synovitis - diagnostic imaging</subject><subject>Ultrasonography - methods</subject><subject>ultrasound</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kL1OwzAURi0EoqUw8ALIYzuk2E6cnwlFpRRQqqK0naPUuRFGSQx2QtWtL4CExBvyJARa2Jjucr6jq4PQOSVDSgi7fGrKIXUdzg9Ql3JOrMCl9iHqEub5lsMCr4NOjHlqUUI95xh1bJ9z3_FoF73dqjW-VmDwsqh1alRTZXhSqFVa4Nl0HIejxef2Y7yMwhjPN5V6lbU0eC6UBtyfRLPxfD7AudI4foSmTGslMxzq-lH_cP04HOBQ1LKdbXBoDBhTQlXjB9DtqMSywjGkxef2PZI5XJ2iozwtDJztbw8tb8aL0a0VzSZ3ozCyBGs_t1aMBzYXTKRCgMPtnAaBT2mQO35GiRDfDZiXCx-oL0TOfXBJBmLlMuq5geB2D_V33metXhowdVJKI6Ao0gpUYxKb2JTazONeiw52qNDKGA158qxlmepNQknyXT9p6yc_9Vv2Yq9tViVkf-Rv7ha43AFrWcDmf1Nyv5zulF-TzI9k</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Andrade, Nicole Pamplona Bueno</creator><creator>Brenol, Claiton Viegas</creator><creator>Silva Chakr, Rafael Mendonça</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1090-3708</orcidid></search><sort><creationdate>202407</creationdate><title>How Does Ultrasound Global OMERACT–EULAR Synovitis Score (GLOESS) for Rheumatoid Arthritis (RA) Activity Assessment Perform in Real‐Life?</title><author>Andrade, Nicole Pamplona Bueno ; Brenol, Claiton Viegas ; Silva Chakr, Rafael Mendonça</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2855-b25935c2cacce453f1998119f48d10cc155027fc8e18ccf58e60decb621769c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>GLOESS</topic><topic>Humans</topic><topic>Male</topic><topic>Metacarpophalangeal Joint - diagnostic imaging</topic><topic>Middle Aged</topic><topic>Reproducibility of Results</topic><topic>rheumatoid arthritis</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>synovitis</topic><topic>Synovitis - diagnostic imaging</topic><topic>Ultrasonography - methods</topic><topic>ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrade, Nicole Pamplona Bueno</creatorcontrib><creatorcontrib>Brenol, Claiton Viegas</creatorcontrib><creatorcontrib>Silva Chakr, Rafael Mendonça</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrade, Nicole Pamplona Bueno</au><au>Brenol, Claiton Viegas</au><au>Silva Chakr, Rafael Mendonça</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How Does Ultrasound Global OMERACT–EULAR Synovitis Score (GLOESS) for Rheumatoid Arthritis (RA) Activity Assessment Perform in Real‐Life?</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2024-07</date><risdate>2024</risdate><volume>43</volume><issue>7</issue><spage>1313</spage><epage>1318</epage><pages>1313-1318</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><abstract>Objective
This study aimed to assess the effectiveness of the Global OMERACT–EULAR Synovitis Score (GLOESS) of bilateral second to fifth metacarpophalangeal joints (MCP 2–5) in evaluating rheumatoid arthritis (RA) activity in a real‐life setting.
Methods
This cross‐sectional study included consecutive RA patients without hyperalgesia. Clinical data were extracted from electronic medical records. Evaluations were conducted on bilateral MCP 2–5 by two independent experts in musculoskeletal ultrasound (MSUS). Correlation between clinical and ultrasonographic parameters was analyzed, aiming to define a cutoff value for detecting disease activity.
Results
Sixty‐nine patients were included. The mean DAS28‐ESR was 4.3 (±1.4), and the median GLOESS was 7 (13). The correlation between GLOESS and DAS28 was moderate (r = .62; P < .05). A total GLOESS score of ≤3 and all joints with both GS and PD ≤1 showed good sensitivity and specificity for detecting disease activity (remission/low vs moderate/high, P = 0).
Conclusion
In a real‐life scenario, GLOESS for MCP 2–5 emerges as a valuable measure of RA activity. The optimal cutoff distinguishing remission/low from moderate/high disease activity was determined to be GLOESS ≤3, with all MCP joints exhibiting both GS and PD scores of ≤1.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38558471</pmid><doi>10.1002/jum.16455</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1090-3708</orcidid></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Arthritis, Rheumatoid - diagnostic imaging Cross-Sectional Studies Female GLOESS Humans Male Metacarpophalangeal Joint - diagnostic imaging Middle Aged Reproducibility of Results rheumatoid arthritis Sensitivity and Specificity Severity of Illness Index synovitis Synovitis - diagnostic imaging Ultrasonography - methods ultrasound |
| title | How Does Ultrasound Global OMERACT–EULAR Synovitis Score (GLOESS) for Rheumatoid Arthritis (RA) Activity Assessment Perform in Real‐Life? |
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