Short, frequent, light‐intensity walking activity improves postprandial vascular‐inflammatory biomarkers in people with type 1 diabetes: The SIT‐LESS randomized controlled trial

• Published in: Diabetes, obesity & metabolism obesity & metabolism, 2024-06, Vol.26 (6), p.2439-2445
• Main Authors: Safdar, Nawaz Z., Alobaid, Anwar M., Hopkins, Mark, Dempsey, Paddy C., Pearson, Sam M., Kietsiriroje, Noppadol, Churm, Rachel, Ajjan, Ramzi A., Campbell, Matthew D.
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Blood Glucose - analysis; Blood Glucose - metabolism; Cross-Over Studies; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 1 - therapy; Exercise; Female; Fibrinogen; Fibrinogen - analysis; Fibrinogen - metabolism; Hemoglobin; Humans; Inflammation; Inflammation - blood; Insulin; Insulin Resistance; Interleukin-1beta - blood; Male; Physical activity; Plasma levels; Plasminogen Activator Inhibitor 1 - blood; Plasminogen activator inhibitors; Postprandial Period - physiology; sedentariness; Sedentary Behavior; thrombosis; Tumor necrosis factor; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; type 1 diabetes; Walking - physiology; Young Adult
• ISSN: 1462-8902; 1463-1326
• DOI: 10.1111/dom.15564

Aim To examine the effect of interrupting prolonged sitting with short, frequent, light‐intensity activity on postprandial cardiovascular markers in people with type 1 diabetes (T1D). Materials and Methods In a randomized crossover trial, 32 adults with T1D (mean ± SD age 28 ± 5 years, glycated haemoglobin 67.9 ± 12.6 mmol/mol, 17 women) completed two 7‐h laboratory visits separated by >7 days. Participants either remained seated for 7 h (SIT) or interrupted sitting with 3‐min bouts of self‐paced walking at 30‐min intervals commencing 1 h after each meal (SIT‐LESS). Physical activity, insulin regimen, experimental start times, and meal consumption were standardized during each arm. Plasma levels of interleukin (IL)‐1β, tumour necrosis factor (TNF)‐α, plasminogen activator inhibitor (PAI)‐1 and fibrinogen were sampled at baseline, 3.5 and 7 h, and assessed for within‐ and between‐group effects using a repeated measures ANOVA. The estimated glucose disposal rate was used to determine the insulin resistance status. Results Vascular‐inflammatory parameters were comparable between SIT and SIT‐LESS at baseline (p > .05). TNF‐α, IL‐1β, PAI‐1 and fibrinogen increased over time under SIT, whereas these rises were attenuated under SIT‐LESS (p