Repeated photodynamic therapy using a chlorin e6‐embedded device to prolong the therapeutic effects on obesity

Objective This study aimed to investigate the efficacy and safety of repeated photodynamic therapy (PDT) with a chlorin e6 (Ce6)‐embedded intragastric satiety‐inducing device (ISD) to maintain therapeutic effects of obesity in a juvenile pig. Methods The Ce6‐embedded ISD was fabricated with a dippin...

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Published in:Obesity (Silver Spring, Md.) Md.), 2024-05, Vol.32 (5), p.911-922
Main Authors: Park, Jung‐Hoon, Kim, Ji Won, Ryu, Dae Sung, Lee, Hyeonseung, Na, Hee Kyong, Noh, Jin Hee, Kim, Do Hoon, Lee, Sanghee, Na, Kun, Jung, Hwoon‐Yong
Format: Article
Language:English
Subjects:
Carbon dioxide
Cell culture
Cytotoxicity
Endoscopy
Esophagus
Gastrointestinal surgery
Hogs
Laboratory animals
Lasers
Obesity
Penicillin
Photodynamic therapy
Silicones
Stomach
Weight control
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Summary:Objective This study aimed to investigate the efficacy and safety of repeated photodynamic therapy (PDT) with a chlorin e6 (Ce6)‐embedded intragastric satiety‐inducing device (ISD) to maintain therapeutic effects of obesity in a juvenile pig. Methods The Ce6‐embedded ISD was fabricated with a dipping method. Twelve pigs were divided into four groups of three and were administered control, single, biweekly, or weekly PDT, respectively. The therapeutic effects were assessed by comparing the results of phototoxicity, endoscopy, fluoroscopy, hormone and weight changes, and histological examination. Results The percentage of total body weight gain was significantly suppressed in PDT‐treated pigs compared with control pigs (all p 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23958