How BDNF affects working memory in acute sleep deprivation: The mediating role of spontaneous brain activity

• Published in: Sleep medicine 2024-06, Vol.118, p.1-8
• Main Authors: Ning, Yanzhe, Feng, Sitong, Zheng, Sisi, Wu, Ziyao, Liu, Xinzi, Dong, Linrui, Jia, Hongxiao
• Format: Article
• Language: English
• Subjects: Adult; Amplitude of low-frequency fluctuation; Brain - diagnostic imaging; Brain - physiopathology; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Female; Functional MRI; Humans; Magnetic Resonance Imaging; Male; Memory, Short-Term - physiology; Sleep deprivation; Sleep Deprivation - blood; Sleep Deprivation - physiopathology; Working memory; Young Adult
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2024.03.027

The brain-derived neurotrophic factor (BDNF) mediates the plasticity associated with memory processing, and compensatorily increases after acute sleep deprivation (SD). However, whether the altered spontaneous brain activity mediates the association between BDNF and working memory in SD remains unknown. Here, we aimed to probe the mediating role of the spontaneous brain activity between plasma BDNF and WM function in SD. A total of 30 healthy subjects with regular sleep were enrolled in this study. Resting-sate functional magnetic resonance imaging (fMRI) scans and the peripheral blood were collected before and after 24 h SD. All participants also received n-back task assessing working memory (WM) performance. The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were calculated to reflect the intensity of regional spontaneous brain activity. Plasma BDNF was measured by sandwich ELISA. Our results revealed a significant decline in WM and increase in plasma BDNF level after SD, and negative association between the changed WM performance and plasma BDNF level. Specially, the ALFF of the left inferior parietal cortex and right inferior frontal cortex, and fALFF of the left anterior cingulate and medial prefrontal cortex and left posterior opercular cortex regulated the association between the BDNF and one-back reaction time respectively. Our results suggest that the association between BDNF and working memory may be mediated through regional spontaneous brain activity involving in the cerebral cortex, which may provide new sight into the interaction between neurotrophic factors and cognition, and potential targets for noninvasive brain stimulation on WM decline after acute SD. •There was a negative correlation between the changed WM and plasma BDNF level after SD.•The altered ALFF/fALFF were negatively associated with WM and plasma BDNF level after SD.•The relationship between BDNF and WM may be mediated by altered ALFF/fALFF in brain regions after SD.