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Comparing efficacy of charged-particle therapy with brachytherapy in treatment of uveal melanoma

Background Uveal melanoma (UM) is the most common primary ocular tumour in adults. The most used eye-preserving treatments are charged-particle therapy (CPT) and brachytherapy. We performed a systematic review and meta-analysis to compare efficacies and complications of these two radiotherapies. Met...

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Bibliographic Details
Published in:Eye (London) 2024-07, Vol.38 (10), p.1882-1890
Main Authors: Tseng, Yu-Hsuan, Hsu, Chia-An, Chou, Yu-Bai
Format: Article
Language:English
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Summary:Background Uveal melanoma (UM) is the most common primary ocular tumour in adults. The most used eye-preserving treatments are charged-particle therapy (CPT) and brachytherapy. We performed a systematic review and meta-analysis to compare efficacies and complications of these two radiotherapies. Methods We searched EMBASE, PubMed, MEDLINE, and the Cochrane Library from January 2012 to December 2022. Two independent reviewers identified controlled studies comparing outcomes of CPT versus brachytherapy. Case series that utilize either treatment modality were also reviewed. Results One hundred fifty studies met the eligibility criteria, including 2 randomized control trials, 5 controlled cohort studies, and 143 case series studies. We found significant reduction in local recurrence rate among patients treated with CPT compared to brachytherapy (Odds ratio[OR] 0.38, 95% Confidence interval [CI] 0.24–0.60, p  
ISSN:0950-222X
1476-5454
1476-5454
DOI:10.1038/s41433-024-03035-y