Takotsubo cardiomyopathy in Guillain–Barré syndrome

• Published in: Journal of neurology 2024-07, Vol.271 (7), p.4067-4074
• Main Authors: Terayama, Atsushi, Kuwahara, Motoi, Yoshikawa, Keisuke, Yamagishi, Yuko, Samukawa, Makoto, Yamashita, Shoko, Onishi, Kyohei, Nagano, Tomoya, Tatsumi, Chikao, Ishii, Junko, Kawamoto, Michi, Tokashiki, Takashi, Deguchi, Shoko, Deguchi, Kentaro, Ishida, Atsushi, Baba, Yasuhiko, Yamaguchi, Shigeki, Kusunoki, Susumu, Nagai, Yoshitaka
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Autoantibodies - blood; Cardiomyopathy; Cranial nerves; Female; Gangliosides - immunology; Guillain-Barre syndrome; Guillain-Barre Syndrome - complications; Guillain-Barre Syndrome - physiopathology; Humans; Male; Mechanical ventilation; Medical research; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neuroradiology; Neurosciences; Original Communication; Patients; Retrospective Studies; Skull; Takotsubo Cardiomyopathy - complications; Takotsubo Cardiomyopathy - etiology; Young Adult
• ISSN: 0340-5354; 1432-1459; 1432-1459
• DOI: 10.1007/s00415-024-12295-3

Background and purpose Takotsubo cardiomyopathy (TCM) is a serious autonomic complication of Guillain–Barré syndrome (GBS). However, the association between TCM and GBS has not been investigated in detail. We investigated the characteristics of GBS patients with TCM (GBS-TCM). Methods Clinical features and anti-ganglioside antibody between the GBS-TCM patients and 62 classical GBS patients without TCM as control patients were compared. Results Eight GBS-TCM patients were identified, in whom TCM was diagnosed at a mean of 6.5 [range 3–42] days after the onset of GBS. The age at onset of GBS was elder in the GBS-TCM patients than in the control GBS patients (76.5 [56–87] vs. 52 [20–88] years, p