Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health

The production of harmful free radicals (H-FRs), especially those with oxygen or nitrogen atoms, depends on both internal and environmental causes. The negative effects of H-FRs are greatly alleviated by antioxidant protection. The harmful impact of oxidative stress, or OS, is brought on by a dispar...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2024-04, Vol.39 (2), p.154-167
Main Author: Mustafa, Yasser Fakri
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Apoptosis
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Free radicals
Hepatitis
Life Sciences
Microbiology
Oxidative stress
Pathology
Review Article
Skeletal muscle
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Summary:The production of harmful free radicals (H-FRs), especially those with oxygen or nitrogen atoms, depends on both internal and environmental causes. The negative effects of H-FRs are greatly alleviated by antioxidant protection. The harmful impact of oxidative stress, or OS, is brought on by a disparity between the defense mechanisms of the body and the creation of H-FRs. Aging is characterized by a slow decline in tissue and organ competence. Age-mediated pathologies start as an aberrant accumulation of H-FRs, which inhibit cells’ capacity to divide, repair, and operate, based on the OS theorem of aging. The natural outcome of this situation is apoptosis. These conditions may include skeletal muscle dysfunction, cancer, cardiovascular, chronic hepatitis, chronic renal, and chronic pulmonary disorders. Given the substantial role that OS plays in the progression of many of these illnesses, antioxidant-based therapy may have a favorable impact on how these diseases progress. To ascertain the true efficacy of this therapy strategy, more research is necessary. The aim of this study is to provide an overview of the literature on this challenging issue that is attracting interest.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-023-01147-y