Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease

Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, the waste clearance system. We evaluated 46 adult patients with MMD and 33 age- and sex-matched controls using diffusivity along the perivascular space (A...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2024-10, Vol.44 (10), p.1787-1800
Main Authors: Hara, Shoko, Kikuta, Junko, Takabayashi, Kaito, Kamagata, Koji, Hayashi, Shihori, Inaji, Motoki, Tanaka, Yoji, Hori, Masaaki, Ishii, Kenji, Nariai, Tadashi, Taoka, Toshiaki, Naganawa, Shinji, Aoki, Shigeki, Maehara, Taketoshi
Format: Article
Language:English
Subjects:
Adult
Cerebrovascular Circulation - physiology
Diffusion Tensor Imaging - methods
Female
Glymphatic System - diagnostic imaging
Glymphatic System - physiopathology
Hemodynamics - physiology
Humans
Male
Middle Aged
Moyamoya Disease - diagnostic imaging
Moyamoya Disease - physiopathology
Positron-Emission Tomography
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Summary:Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, the waste clearance system. We evaluated 46 adult patients with MMD and 33 age- and sex-matched controls using diffusivity along the perivascular space (ALPS) measured with diffusion tensor imaging (ALPS index), which may partly reflect glymphatic system activity, and multishell diffusion MRI to generate freewater maps. Twenty-three patients were also evaluated via 15O-gas positron emission tomography (PET), and all patients underwent cognitive tests. Compared to controls, patients (38.4 (13.2) years old, 35 females) had lower ALPS indices in the left and right hemispheres (1.94 (0.27) vs. 1.65 (0.25) and 1.94 (0.22) vs. 1.65 (0.19), P 
ISSN:0271-678X
1559-7016
1559-7016
DOI:10.1177/0271678X241245492