Cholangiocarcinoma imaging: from diagnosis to response assessment

Cholangiocarcinoma (CCA), a highly aggressive primary liver cancer arising from the bile duct epithelium, represents a substantial proportion of hepatobiliary malignancies, posing formidable challenges in diagnosis and treatment. Notably, the global incidence of intrahepatic CCA has seen a rise, nec...

Full description

Saved in:
Bibliographic Details
Published in:Abdominal imaging 2024-05, Vol.49 (5), p.1699-1715
Main Authors: Cao, Jinjin, Srinivas-Rao, Shravya, Mroueh, Nayla, Anand, Roshni, Kongboonvijit, Sasiprang, Sertic, Madeleine, Shenoy-Bhangle, Anuradha S., Kambadakone, Avinash
Format: Article
Language:English
Subjects:
Bile Duct Neoplasms - diagnostic imaging
Bile ducts
Cholangiocarcinoma
Cholangiocarcinoma - diagnostic imaging
Computed tomography
Diagnosis
Diagnosis, Differential
Epithelium
Evaluation
Gastroenterology
Hepatocellular carcinoma
Hepatology
Humans
Imaging
Liver cancer
Magnetic resonance imaging
Malignancy
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Neoplasm Staging
Positron emission
Positron emission tomography
Radiology
Review
Risk factors
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cholangiocarcinoma (CCA), a highly aggressive primary liver cancer arising from the bile duct epithelium, represents a substantial proportion of hepatobiliary malignancies, posing formidable challenges in diagnosis and treatment. Notably, the global incidence of intrahepatic CCA has seen a rise, necessitating a critical examination of diagnostic and management strategies, especially due to presence of close imaging mimics such as hepatocellular carcinoma (HCC) and combined hepatocellular carcinoma–cholangiocarcinoma (cHCC–CCA). Hence, it is imperative to understand the role of various imaging modalities such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), elucidating their strengths, and limitations in diagnostic precision and staging accuracy. Beyond conventional approaches, there is emerging significance of functional imaging tools including positron emission tomography (PET)–CT and diffusion-weighted (DW)-MRI, providing pivotal insights into diagnosis, therapeutic assessment, and prognostic evaluation. This comprehensive review explores the risk factors, classification, clinical features, and role of imaging in the holistic spectrum of diagnosis, staging, management, and restaging for CCA, hence serving as a valuable resource for radiologists evaluating CCA.
ISSN:2366-0058
2366-004X
2366-0058
DOI:10.1007/s00261-024-04267-y