Graphdiyne marries PEDOT:PSS to form high-stable heterostructure from 2-unstable components toward ultra-low detection limit of uric acid detection in sweat

PEDOT:PSS has been used as a biomimetic uric acid (UA) sensor but suffers from unfortunate low detection limit (LOD), narrow detection range and poor stability. Herein, we get graphdiyne (GDY) marry PEDOT:PSS to create a very stable GDY@PEDOT:PSS heterostructure for a biomimetic UA sensor, which acc...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2024-05, Vol.191 (5), p.243-243, Article 243
Main Authors: Li, Yunpeng, Shi, Zhuanzhuan, Wu, Xiaoshuai, Miao, Wenting, Yang, Zhengyi, Lou, Xinyu, Sun, Wei, Guo, Chunxian, Li, Chang Ming
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biomimetics
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Graphite
Heterostructures
Limit of Detection
Microengineering
Nanochemistry
Nanotechnology
Oxidation resistance
Sensors
Short Communication
Stability
Sweat
Uric Acid
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Summary:PEDOT:PSS has been used as a biomimetic uric acid (UA) sensor but suffers from unfortunate low detection limit (LOD), narrow detection range and poor stability. Herein, we get graphdiyne (GDY) marry PEDOT:PSS to create a very stable GDY@PEDOT:PSS heterostructure for a biomimetic UA sensor, which accomplishes the lowest LOD (6 nM), the widest detection range (0.03 μM-7 mM) and the longest stability (98.1% for 35 days) among the related UA sensors. The sensor was successfully used to in situ real-time detection of  UA in sweat. The enhancement mechanisms of the sensor were investigated, and results discover that C≡C of GDY and C = C of PEDOT:PSS can cross-link each other by π–π interactions, making not only the former strongly resistant against oxidation deterioration, but also causes the latter to efficiently prevent water swelling of polymer for poor conductivity, thereby leading to high stability from both components. While the stabilized heterostructure can also offer more active sites by enhanced absorption of UA via π-π interactions for highly sensitive detection of UA. This work holds great promise for a practical sweat UA sensor while providing scientific insight to design a stable and electrocatalytically active structure from two unstable components. Graphical abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-024-06311-6