Drug-induced lupus erythematosus in childhood: Case-based review

• Published in: Lupus 2024-06, Vol.33 (7), p.737-748
• Main Authors: Kaya Akca, Ummusen, Sener, Seher, Batu, Ezgi Deniz, Balik, Zeynep, Basaran, Ozge, Bilginer, Yelda, Ozen, Seza
• Format: Article
• Language: English
• Subjects: Adolescent; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Antinuclear antibodies; Arthralgia; Child; Child, Preschool; Children; Corticosteroids; Doxycycline; Doxycycline - adverse effects; Etanercept; Etanercept - adverse effects; Ethosuximide - adverse effects; Female; Histones; Humans; Literature reviews; Lupus; Lupus Erythematosus, Systemic - chemically induced; Lupus Erythematosus, Systemic - drug therapy; Male; Minocycline; Minocycline - adverse effects; Patients; Topiramate; Topiramate - adverse effects
• ISSN: 0961-2033; 1477-0962; 1477-0962
• DOI: 10.1177/09612033241245078

Background Drug-induced lupus erythematosus (DILE) is the development of lupus-like syndrome following a drug exposure. DILE has been reported less frequently among children than adults. Methods In this study, we present four children with DILE and similar published cases through a systematic literature review. Results We report four children (three girls and one boy) who developed DILE associated with the use of topiramate, doxycycline, etanercept, and ethosuximide. Three of them were positive for anti-histone antibodies. In all patients, the drug was discontinued and symptoms resolved completely. The literature review revealed 48 articles describing 61 children with DILE. In the evaluation of 65 patients (our 4 patients and 61 patients from the literature), the most frequently reported drugs associated with DILE were ethosuximide (n = 13) and minocycline (n = 12). Fever (n = 33), arthralgia (n = 31), rash (n = 30), and arthritis (n = 29) were the most common clinical manifestations. Antinuclear antibody (ANA) was positive in 93.5% of patients and anti-histone antibodies were detected in 72.2% of the patients. As for treatment, the responsible drug was discontinued in all patients, and corticosteroids were initiated in 53.3%. Improvement was achieved in 92.0% of patients. Conclusion For children presenting with SLE features, proper drug history is crucial since DILE may be more frequent than anticipated. An association of the relevant drug with the symptoms, and resolution of symptoms on drug withdrawal provides evidence for the diagnosis of DILE.