Four Streams Within the Prefrontal Cortex: Integrating Structural and Functional Connectivity

Merging functional evidence derived from studies of autism spectrum disorder and attention-deficit/hyperactivity disorder converges in four neural streams of the prefrontal cortex, hence suggesting a model of information processing through four streams: motor through Brodmann area (BA) 8, emotion th...

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Bibliographic Details
Published in:The Neuroscientist (Baltimore, Md.) Md.), 2024-04, p.10738584241245304-10738584241245304
Main Authors: Ben Shalom, Dorit, Skandalakis, Georgios P
Format: Article
Language:English
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Summary:Merging functional evidence derived from studies of autism spectrum disorder and attention-deficit/hyperactivity disorder converges in four neural streams of the prefrontal cortex, hence suggesting a model of information processing through four streams: motor through Brodmann area (BA) 8, emotion through BA 9, memory through BA 10, and emotional-related sensory through BA 11. A growing body of functional data has been supporting this model of information processing. Nevertheless, the underlying structural connectivity was only recently unveiled by a population-based high-definition tractography study with data from 1,065 individuals. This update provides a brief overview of recent evidence supporting the anatomofunctional integration of the four streams of the prefrontal cortex and reviews the white matter fiber tracts subserving the four streams.
ISSN:1073-8584
1089-4098
DOI:10.1177/10738584241245304