Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors

• Published in: Journal of cellular physiology 2024-06, Vol.239 (6), p.e31265-n/a
• Main Authors: Proença, Ana Beatriz, Medeiros, Gabriela Rodrigues, Reis, Guilherme dos Santos, Losito, Luiza da França, Ferraz, Luiza Mazzali, Bargut, Thereza Cristina Lonzetti, Soares, Nícia Pedreira, Alexandre‐Santos, Beatriz, Campagnole‐Santos, Maria Jose, Magliano, D'Angelo Carlo, Nobrega, Antonio Claudio Lucas da, Santos, Robson Augusto Souza, Frantz, Eliete Dalla Corte
• Format: Article
• Language: English
• Subjects: Adipogenesis; Adipose tissue; Adipose tissue (brown); Adipose Tissue - metabolism; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - metabolism; Angiotensin AT1 receptors; Angiotensin receptors; Animals; beige adipocytes; Body fat; brown adipose tissue (BAT); Endocrine system; Energy balance; Energy Metabolism; Homeostasis; Humans; Inflammation; Lipolysis; Mas receptor; Metabolism; MrgD receptor; Obesity; Obesity - metabolism; Obesity - pathology; Plastic foam; Plastic properties; Plasticity; Proto-Oncogene Mas; Receptors; Receptors, G-Protein-Coupled - metabolism; Renin; Renin-Angiotensin System - physiology; renin‐angiotensin system (RAS); Signal Transduction; Thermogenesis; Thermogenesis - physiology; white adipose tissue (WAT)
• ISSN: 0021-9541; 1097-4652; 1097-4652
• DOI: 10.1002/jcp.31265

The renin‐angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity‐associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation of two receptors, the G protein‐coupled receptor (MasR) and Mas‐related receptor type D (MrgD). The local RAS in adipose organ has prompted extensive research into white adipose tissue and brown adipose tissue (BAT), with a key role in regulating the cellular and metabolic plasticity of these tissues. The MasR activation favors the brown plasticity signature in the adipose organ by improve the thermogenesis, adipogenesis, and lipolysis, decrease the inflammatory state, and overall energy homeostasis. The MrgD metabolic effects are related to the maintenance of BAT functionality, but the signaling remains unexplored. This review provides a summary of RAS counterregulatory actions triggered by Mas and MrgD receptors on adipose tissue plasticity. Focus on the effects related to the morphology and function of adipose tissue, especially from animal studies, will be given targeting new avenues for treatment of obesity‐associated metabolic effects.