Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering

Inspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and propelling medical breakthroughs. Therefore, medical, and pharmaceutical fields are growing interest in tissue and organ replacement, repair, an...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmaceutical sciences 2024-05, Vol.196, p.106761-106761, Article 106761
Main Authors: Sanchez Armengol, Eva, Hock, Nathalie, Saribal, Sila, To, Dennis, Summonte, Simona, Veider, Florina, Kali, Gergely, Bernkop-Schnürch, Andreas, Laffleur, Flavia
Format: Article
Language:English
Subjects:
Biomimetic
Chitosan
Keratin
Scaffolds
Tissue engineering
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and propelling medical breakthroughs. Therefore, medical, and pharmaceutical fields are growing interest in tissue and organ replacement, repair, and regeneration by this technology. Three primary mechanisms are currently used in tissue engineering: transplantation of cells (I), injection of growth factors (II) and cellular seeding in scaffolds (III). However, to develop scaffolds presenting highest potential, reinforcement with polymeric materials is growing interest. For instance, natural and synthetic polymers can be used. Regardless, chitosan and keratin are two biopolymers presenting great biocompatibility, biodegradability and non-antigenic properties for tissue engineering purposes offering restoration and revitalization. Therefore, combination of chitosan and keratin has been studied and results exhibit highly porous scaffolds providing optimal environment for tissue cultivation. This review aims to give an historical as well as current overview of tissue engineering, presenting mechanisms used and polymers involved in the field. [Display omitted]
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2024.106761