Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection

Abstract The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflamm...

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Bibliographic Details
Published in:Open forum infectious diseases 2024-04, Vol.11 (4), p.ofae170
Main Authors: Elliott, Eric I, Smith, Daisy, Lipscomb, Jonathan, Banini, Bubu, Meurer, Lindsay, Vanderford, Thomas H, Johnson, Jeffrey A, Jain, Dhanpat, Achhra, Amit
Format: Article
Language:English
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Summary:Abstract The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofae170