Green Synthesis of Selenium Nanoparticles From Clove and Their Toxicity Effect and Anti-angiogenic, Antibacterial and Antioxidant Potential

• Published in: Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e55605-e55605
• Main Authors: Behera, Archana, Dharmalingam Jothinathan, Mukesh Kumar, Saravanan, Saantosh, Tamil Selvan, Silambarasan, Rajan Renuka, Remya, Srinivasan, Guru Prasad
• Format: Article
• Language: English
• Subjects: Acids; Antioxidants; Bacteria; Cancer; Cell death; Environmental science; Gram-positive bacteria; Humidity; Nanomaterials; Nanoparticles; Phytochemicals; Scanning electron microscopy; Seawater; Selenium; Spectrum analysis; Sustainable practices; Toxicity; Toxicity testing; Ultraviolet spectroscopy
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.55605

Introduction  Nanoparticles, owing to their minuscule size, have become pivotal in diverse scientific endeavors, presenting unique characteristics with applications spanning medicine to environmental science. Selenium nanoparticles (SeNPs) exhibit potential in diverse biomedical uses. Aim This research investigates the potential anti-inflammatory and anticancer properties of SeNPs, which are synthesized using the green synthesis method. This eco-friendly approach aligns with sustainable practices and utilizes clove extract ( ). Materials and methods Clove extract facilitates SeNP synthesis via sodium selenite reduction. The characterization methods comprised Fourier-transform infrared (FTIR) spectroscopy, UV-VIS spectroscopy, and scanning electron microscopy (SEM). Assessments covered antioxidant properties, chorioallantoic membrane assay (CAM) assay for antiangiogenic effects, toxicity evaluation, and antibacterial assays. Results Successful synthesis of SeNPs was verified by a UV-visible absorption peak at 256 nm and FTIR peaks around 3500-500 cm  , and the spherical morphology was confirmed by SEM analysis with EDAX, which indicated the presence of SeNPs and their unique properties. Phytochemical substances are active chemicals that contribute to the properties of SeNPs. The SeNPs exhibited antioxidant activity with an IC50 value of 0.437 µg/mL and antibacterial properties against bacterial pathogen  , with a zone of inhibition measuring 19 mm. The CAM assay demonstrated possible antiangiogenic actions, and toxicity testing on showed biocompatibility. Conclusion This study underscores the efficient synthesis of SeNPs using clove extract, emphasizing their potential applications. The notable properties of SeNPs emphasize their promise for diverse biomedical and environmental uses.