Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial

BACKGROUND: Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared with intravenous tranexamic acid, which may lower the risk of seizures. We aimed to determine whether topical tranex...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2024-10, Vol.150 (17), p.1315-1323
Main Authors: Lamy, André, Sirota, Dmitry A., Jacques, Frederic, Poostizadeh, Ahmad, Noiseux, Nicolas, Efremov, Sergey, Demers, Philippe, Akselrod, Boris, Wang, Chew Yin, Arora, Rakesh C., Branny, Piotr, McGuinness, Shay P., Brown, Craig D., Jeanmart, Hugues, Zhao, Qiang, Zhang, Haibo, Belley-Côté, Emilie P., Whitlock, Richard P., Browne, Austin, Copland, Ingrid, Vincent, Jessica, Khatun, Rutaba, Balasubramanian, Kumar, Bangdiwala, Shrikant I., McGillion, Michael H., Fox-Robichaud, Alison E., Spence, Jessica, Yusuf, Salim, Devereaux, P.J.
Format: Article
Language:English
Subjects:
Administration, Intravenous
Administration, Topical
Aged
Antifibrinolytic Agents - administration & dosage
Antifibrinolytic Agents - adverse effects
Antifibrinolytic Agents - therapeutic use
Blood Loss, Surgical - prevention & control
Cardiac Surgical Procedures - adverse effects
Double-Blind Method
Female
Humans
Male
Middle Aged
Seizures - etiology
Seizures - prevention & control
Tranexamic Acid - administration & dosage
Tranexamic Acid - adverse effects
Tranexamic Acid - therapeutic use
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!