Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

Carpesabrolide A (1), featuring an unprecedented fumaric acid-guaiane sesquiterpenoid hybrid, has been isolated from the folk medicinal plant . The structure with absolute configuration has been established by spectroscopic methods and single crystal X-ray diffraction analysis. The plausible biosynt...

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Bibliographic Details
Published in:RSC advances 2024-04, Vol.14 (16), p.11002-11006
Main Authors: Zhang, Xiao-Fang, Du, Jiao-Xian, Teng, Si-Qiong, Liu, Hui, He, Juan, Feng, Tao, Liu, Ji-Kai
Format: Article
Language:English
Subjects:
Fumaric acid
Herbal medicine
Single crystals
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Summary:Carpesabrolide A (1), featuring an unprecedented fumaric acid-guaiane sesquiterpenoid hybrid, has been isolated from the folk medicinal plant . The structure with absolute configuration has been established by spectroscopic methods and single crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1 is proposed. Compound 1 shows significant anti-inflammatory activity by inhibiting NO production with an IC value of 2.7 μM.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra00292j