Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period

This study investigated the impact of neonatal exposure to endocrine-active compounds (EACs): flutamide (antiandrogen), 4-tert-octylphenol (an estrogenic compound), and methoxychlor (an organochlorine insecticide exhibiting estrogenic, antiestrogenic and antiandrogenic activities) on androgen produc...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2024-04, Vol.107, p.104435-104435, Article 104435
Main Authors: Knapczyk-Stwora, Katarzyna, Kozlowska, Aleksandra, Jastrzabek, Damian, Grzesiak, Malgorzata, Slomczynska, Maria, Koziorowski, Marek
Format: Article
Language:English
Subjects:
Adrenal glands
Androgen biosynthesis
Artificial feeding
Endocrine-active compounds
Natural feeding
Pig
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Summary:This study investigated the impact of neonatal exposure to endocrine-active compounds (EACs): flutamide (antiandrogen), 4-tert-octylphenol (an estrogenic compound), and methoxychlor (an organochlorine insecticide exhibiting estrogenic, antiestrogenic and antiandrogenic activities) on androgen production within porcine adrenal glands. The expression of genes related to androgen synthesis and the level of androgen production were analyzed (i) in the adrenal glands of piglets exposed to EACs during the first 10 days of life (in vivo study), and (ii) in adrenal explants from sow-fed or formula-fed 10-day-old piglets incubated with EACs (ex vivo study). EACs affected the expression of genes linked to adrenal androgen biosynthesis. The prominent effect of methoxychlor on downregulation of StAR, CYP11A1 and HSD3B and upregulation of CYP17A1 and SULT2A1 were demonstrated. Furthermore, our study revealed divergent response to EACs between sow-fed and formula-fed piglets, suggesting that natural feeding may provide protection against adverse EACs effects, particularly those interfering with estrogens action. •EACs effects on the adrenal androgen production were studied in piglets.•OP elevated A4, while high dose of MXC reduced DHEA adrenal secretion.•MXC decreased StAR, CYP11A1 and HSD3B, while increased CYP17A1 and SULT2A1 expression.•Divergent EACs effects were observed in sow-fed vs. formula-fed piglets.•Natural feeding influences expression levels of some androgen synthesis-related genes.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2024.104435