The Production of Polysarcosine-Containing Nanoparticles by Ring-Opening Polymerization-Induced Self-Assembly

N-carboxyanhydride ring-opening polymerization-induced self-assembly (NCA ROPISA) offers a convenient route for generating poly(amino acid)-based nanoparticles in a single step, crucially avoiding the need for post-polymerization self-assembly. Most examples of NCA ROPISA make use of a poly(ethylene...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2024-08, Vol.45 (15), p.e2400103
Main Authors: Morrell, Anna H, Warren, Nicholas J, Thornton, Paul D
Format: Article
Language:English
Subjects:
Alanine
Amino acids
Biodegradation
Chemical synthesis
Hydrophobic and Hydrophilic Interactions
Hydrophobicity
Immune response
Immunology
Molecular Structure
Nanoparticles
Nanoparticles - chemistry
Particle Size
Peptides
Phenylalanine
Polyethylene glycol
Polyethylene Glycols - chemistry
Polymerization
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Protein structure
Ring opening polymerization
Sarcosine - analogs & derivatives
Sarcosine - chemistry
Secondary structure
Self-assembly
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Summary:N-carboxyanhydride ring-opening polymerization-induced self-assembly (NCA ROPISA) offers a convenient route for generating poly(amino acid)-based nanoparticles in a single step, crucially avoiding the need for post-polymerization self-assembly. Most examples of NCA ROPISA make use of a poly(ethylene glycol) (PEG) hydrophilic stabilizing block, however this non-biodegradable, oil-derived polymer may cause an immunological response in some individuals. Alternative water-soluble polymers are therefore highly sought. This work reports the synthesis of wholly poly(amino acid)-based nanoparticles, through the chain-extension of a polysarcosine macroinitiator with L-Phenylalanine-NCA (L-Phe-NCA) and Alanine-NCA (Ala-NCA), via aqueous NCA ROPISA. The resulting polymeric structures comprise of predominantly anisotropic, rod-like nanoparticles, with morphologies primarily influenced by the secondary structure of the hydrophobic poly(amino acid) that enables their formation.
ISSN:1022-1336
1521-3927
1521-3927
DOI:10.1002/marc.202400103