A new triterpenoid saponin and a new natural saponin from the roots of Bupleurum scorzonerifolium willd

Sixteen triterpenoid saponins were isolated from the roots of Willd., including a new triterpenoid saponin and new natural saponin that was characterised by NMR for the first time, along with 14 known triterpenoid saponins. The structures of the compounds were established by 1D and 2D NMR spectrosco...

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Published in:Natural product research 2024-04, p.1-8
Main Authors: Li, Zi-Wei, Wu, Jia-Tong, Bi, Yu, Li, Meng-Meng, Naseem, Anam, Pan, Juan, Guan, Wei, Hao, Zhi-Chao, Kuang, Hai-Xue, Chen, Qing-Shan, Zhang, Li-Li, Liu, Yan, Yang, Bing-You
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container_title Natural product research
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creator Li, Zi-Wei
Wu, Jia-Tong
Bi, Yu
Li, Meng-Meng
Naseem, Anam
Pan, Juan
Guan, Wei
Hao, Zhi-Chao
Kuang, Hai-Xue
Chen, Qing-Shan
Zhang, Li-Li
Liu, Yan
Yang, Bing-You
description Sixteen triterpenoid saponins were isolated from the roots of Willd., including a new triterpenoid saponin and new natural saponin that was characterised by NMR for the first time, along with 14 known triterpenoid saponins. The structures of the compounds were established by 1D and 2D NMR spectroscopy, HR-ESI-MS, and comparison with the literature. The cytotoxic activity of the compounds against 4T1 cells was determined using the CCK8 method. Compounds and showed the strongest cytotoxic activity with values of 2.75 ± 0.86 and 3.78 ± 0.50 μM, respectively. Compounds and showed potent cytotoxic activity. Compounds and showed moderate cytotoxicity.
doi_str_mv 10.1080/14786419.2024.2338827
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title A new triterpenoid saponin and a new natural saponin from the roots of Bupleurum scorzonerifolium willd
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