Loading…
Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US
Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed. A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescrip...
Saved in:
Published in: | Respiratory medicine 2024-05, Vol.226, p.107630, Article 107630 |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c307t-fdfc7e0774fc7fa8da6135a5694fd41edf14c24e7d4195871c69b2806a0155a73 |
container_end_page | |
container_issue | |
container_start_page | 107630 |
container_title | Respiratory medicine |
container_volume | 226 |
creator | Roberts, Melissa H. Duh, Mei Sheng Rothnie, Kieran J. Zhang, Shiyuan Czira, Alexandrosz Slade, David Cheng, Wendy Y. Thompson-Leduc, Philippe Greatsinger, Alexandra Zhang, Adina Mapel, Douglas |
description | Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed.
A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescription claim for inhaled corticosteroid/long-acting β2-agonist, and ≥1 medical claim with a diagnosis code for asthma was conducted. The objective was to refine current algorithms to identify moderate exacerbations in claims data and assess the refined algorithm's performance. Positive and negative predictive values (PPV and NPV) were assessed via chart review of 150 moderate exacerbations events and 50 patients without exacerbations. Sensitivity analyses assessed alternative algorithms and compared healthcare resource utilization (HRU) between algorithm-identified patients (claims group) and those confirmed by chart review (confirmed group) to have experienced a moderate exacerbation.
Algorithm-identified moderate exacerbations were: visit of ≤1 day with an asthma exacerbation diagnosis OR visit of ≤1 day with selected asthma diagnoses AND ≥1 respiratory pharmacy claim, excluding systemic corticosteroids, within 14 days after the first claim. The algorithm's PPV was 42%; the NPV was 78%. HRU was similar for both groups.
This algorithm identified potential moderate exacerbations from claims data; however, the modest PPV underscores its limitations in identifying moderate exacerbations, although performance was partially due to identification of previously unidentified severe exacerbations. Application of this algorithm in future claims-based studies may help quantify the economic burden of moderate and severe exacerbations in asthma when an algorithm identifying severe exacerbations is applied first.
•Definitions of moderate asthma exacerbation have been inconsistent (68/85 characters incl. spaces).•An algorithm was refined to identify moderate exacerbations in claims data (76/85 characters incl. spaces).•The algorithm may help quantify economic burden of moderate exacerbations in asthma (85/85 characters incl. spaces). |
doi_str_mv | 10.1016/j.rmed.2024.107630 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3035539228</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0954611124001045</els_id><sourcerecordid>3035539228</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-fdfc7e0774fc7fa8da6135a5694fd41edf14c24e7d4195871c69b2806a0155a73</originalsourceid><addsrcrecordid>eNp9kL1uFDEUhS0EIkvgBVIglzSz2OOfmZHSRAl_UiQKSG3dta8Tr2bGi-1dsjUvjodNWqpr-57vSP4IueBszRnXH7frNKFbt6yV9aHTgr0gK65E2wim5UuyYoOSjeacn5E3OW8ZY4OU7DU5E70aRN_rFflzgwcc427CuVCYHT3AGByUEGcaPQVqRwhTbjaQ0VEY72MK5WGiJdLgKhP8kU7RYYKCFB_BYtr8ozMNM93VYw1l-rtCFHIlgZaENeyWfXlAevfjLXnlYcz47mmek7vPn35ef21uv3_5dn1121jButJ4522HrOtknR56B5oLBUoP0jvJ0XkubSuxq5dB9R23eti0PdPAuFLQiXPy4dS7S_HXHnMxU8gWxxFmjPtsBBNKiaFt-xptT1GbYs4JvdmlMEE6Gs7MIt9szSLfLPLNSX6F3j_17zfL7hl5tl0Dl6cA1l8eAiaTbfVj0YWEthgXw__6_wK55peP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3035539228</pqid></control><display><type>article</type><title>Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US</title><source>Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)</source><creator>Roberts, Melissa H. ; Duh, Mei Sheng ; Rothnie, Kieran J. ; Zhang, Shiyuan ; Czira, Alexandrosz ; Slade, David ; Cheng, Wendy Y. ; Thompson-Leduc, Philippe ; Greatsinger, Alexandra ; Zhang, Adina ; Mapel, Douglas</creator><creatorcontrib>Roberts, Melissa H. ; Duh, Mei Sheng ; Rothnie, Kieran J. ; Zhang, Shiyuan ; Czira, Alexandrosz ; Slade, David ; Cheng, Wendy Y. ; Thompson-Leduc, Philippe ; Greatsinger, Alexandra ; Zhang, Adina ; Mapel, Douglas</creatorcontrib><description>Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed.
A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescription claim for inhaled corticosteroid/long-acting β2-agonist, and ≥1 medical claim with a diagnosis code for asthma was conducted. The objective was to refine current algorithms to identify moderate exacerbations in claims data and assess the refined algorithm's performance. Positive and negative predictive values (PPV and NPV) were assessed via chart review of 150 moderate exacerbations events and 50 patients without exacerbations. Sensitivity analyses assessed alternative algorithms and compared healthcare resource utilization (HRU) between algorithm-identified patients (claims group) and those confirmed by chart review (confirmed group) to have experienced a moderate exacerbation.
Algorithm-identified moderate exacerbations were: visit of ≤1 day with an asthma exacerbation diagnosis OR visit of ≤1 day with selected asthma diagnoses AND ≥1 respiratory pharmacy claim, excluding systemic corticosteroids, within 14 days after the first claim. The algorithm's PPV was 42%; the NPV was 78%. HRU was similar for both groups.
This algorithm identified potential moderate exacerbations from claims data; however, the modest PPV underscores its limitations in identifying moderate exacerbations, although performance was partially due to identification of previously unidentified severe exacerbations. Application of this algorithm in future claims-based studies may help quantify the economic burden of moderate and severe exacerbations in asthma when an algorithm identifying severe exacerbations is applied first.
•Definitions of moderate asthma exacerbation have been inconsistent (68/85 characters incl. spaces).•An algorithm was refined to identify moderate exacerbations in claims data (76/85 characters incl. spaces).•The algorithm may help quantify economic burden of moderate exacerbations in asthma (85/85 characters incl. spaces).</description><identifier>ISSN: 0954-6111</identifier><identifier>ISSN: 1532-3064</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2024.107630</identifier><identifier>PMID: 38593886</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones - administration & dosage ; Adrenal Cortex Hormones - therapeutic use ; Adrenergic beta-2 Receptor Agonists - administration & dosage ; Adrenergic beta-2 Receptor Agonists - therapeutic use ; Adult ; Aged ; Algorithms ; Asthma - diagnosis ; Asthma - drug therapy ; Asthma - economics ; Cohort Studies ; Disease Progression ; Female ; Healthcare economics ; Healthcare resource utilization (max. 6) ; Humans ; Insurance Claim Review ; Male ; Middle Aged ; Moderate exacerbations ; Retrospective Studies ; United States ; Young Adult</subject><ispartof>Respiratory medicine, 2024-05, Vol.226, p.107630, Article 107630</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-fdfc7e0774fc7fa8da6135a5694fd41edf14c24e7d4195871c69b2806a0155a73</cites><orcidid>0000-0001-7451-7756 ; 0000-0001-5035-6687 ; 0000-0003-4279-1624 ; 0000-0001-9047-3941</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38593886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, Melissa H.</creatorcontrib><creatorcontrib>Duh, Mei Sheng</creatorcontrib><creatorcontrib>Rothnie, Kieran J.</creatorcontrib><creatorcontrib>Zhang, Shiyuan</creatorcontrib><creatorcontrib>Czira, Alexandrosz</creatorcontrib><creatorcontrib>Slade, David</creatorcontrib><creatorcontrib>Cheng, Wendy Y.</creatorcontrib><creatorcontrib>Thompson-Leduc, Philippe</creatorcontrib><creatorcontrib>Greatsinger, Alexandra</creatorcontrib><creatorcontrib>Zhang, Adina</creatorcontrib><creatorcontrib>Mapel, Douglas</creatorcontrib><title>Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed.
A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescription claim for inhaled corticosteroid/long-acting β2-agonist, and ≥1 medical claim with a diagnosis code for asthma was conducted. The objective was to refine current algorithms to identify moderate exacerbations in claims data and assess the refined algorithm's performance. Positive and negative predictive values (PPV and NPV) were assessed via chart review of 150 moderate exacerbations events and 50 patients without exacerbations. Sensitivity analyses assessed alternative algorithms and compared healthcare resource utilization (HRU) between algorithm-identified patients (claims group) and those confirmed by chart review (confirmed group) to have experienced a moderate exacerbation.
Algorithm-identified moderate exacerbations were: visit of ≤1 day with an asthma exacerbation diagnosis OR visit of ≤1 day with selected asthma diagnoses AND ≥1 respiratory pharmacy claim, excluding systemic corticosteroids, within 14 days after the first claim. The algorithm's PPV was 42%; the NPV was 78%. HRU was similar for both groups.
This algorithm identified potential moderate exacerbations from claims data; however, the modest PPV underscores its limitations in identifying moderate exacerbations, although performance was partially due to identification of previously unidentified severe exacerbations. Application of this algorithm in future claims-based studies may help quantify the economic burden of moderate and severe exacerbations in asthma when an algorithm identifying severe exacerbations is applied first.
•Definitions of moderate asthma exacerbation have been inconsistent (68/85 characters incl. spaces).•An algorithm was refined to identify moderate exacerbations in claims data (76/85 characters incl. spaces).•The algorithm may help quantify economic burden of moderate exacerbations in asthma (85/85 characters incl. spaces).</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adrenergic beta-2 Receptor Agonists - administration & dosage</subject><subject>Adrenergic beta-2 Receptor Agonists - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Asthma - diagnosis</subject><subject>Asthma - drug therapy</subject><subject>Asthma - economics</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Healthcare economics</subject><subject>Healthcare resource utilization (max. 6)</subject><subject>Humans</subject><subject>Insurance Claim Review</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Moderate exacerbations</subject><subject>Retrospective Studies</subject><subject>United States</subject><subject>Young Adult</subject><issn>0954-6111</issn><issn>1532-3064</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kL1uFDEUhS0EIkvgBVIglzSz2OOfmZHSRAl_UiQKSG3dta8Tr2bGi-1dsjUvjodNWqpr-57vSP4IueBszRnXH7frNKFbt6yV9aHTgr0gK65E2wim5UuyYoOSjeacn5E3OW8ZY4OU7DU5E70aRN_rFflzgwcc427CuVCYHT3AGByUEGcaPQVqRwhTbjaQ0VEY72MK5WGiJdLgKhP8kU7RYYKCFB_BYtr8ozMNM93VYw1l-rtCFHIlgZaENeyWfXlAevfjLXnlYcz47mmek7vPn35ef21uv3_5dn1121jButJ4522HrOtknR56B5oLBUoP0jvJ0XkubSuxq5dB9R23eti0PdPAuFLQiXPy4dS7S_HXHnMxU8gWxxFmjPtsBBNKiaFt-xptT1GbYs4JvdmlMEE6Gs7MIt9szSLfLPLNSX6F3j_17zfL7hl5tl0Dl6cA1l8eAiaTbfVj0YWEthgXw__6_wK55peP</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Roberts, Melissa H.</creator><creator>Duh, Mei Sheng</creator><creator>Rothnie, Kieran J.</creator><creator>Zhang, Shiyuan</creator><creator>Czira, Alexandrosz</creator><creator>Slade, David</creator><creator>Cheng, Wendy Y.</creator><creator>Thompson-Leduc, Philippe</creator><creator>Greatsinger, Alexandra</creator><creator>Zhang, Adina</creator><creator>Mapel, Douglas</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7451-7756</orcidid><orcidid>https://orcid.org/0000-0001-5035-6687</orcidid><orcidid>https://orcid.org/0000-0003-4279-1624</orcidid><orcidid>https://orcid.org/0000-0001-9047-3941</orcidid></search><sort><creationdate>202405</creationdate><title>Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US</title><author>Roberts, Melissa H. ; Duh, Mei Sheng ; Rothnie, Kieran J. ; Zhang, Shiyuan ; Czira, Alexandrosz ; Slade, David ; Cheng, Wendy Y. ; Thompson-Leduc, Philippe ; Greatsinger, Alexandra ; Zhang, Adina ; Mapel, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-fdfc7e0774fc7fa8da6135a5694fd41edf14c24e7d4195871c69b2806a0155a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adrenergic beta-2 Receptor Agonists - administration & dosage</topic><topic>Adrenergic beta-2 Receptor Agonists - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Asthma - diagnosis</topic><topic>Asthma - drug therapy</topic><topic>Asthma - economics</topic><topic>Cohort Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Healthcare economics</topic><topic>Healthcare resource utilization (max. 6)</topic><topic>Humans</topic><topic>Insurance Claim Review</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Moderate exacerbations</topic><topic>Retrospective Studies</topic><topic>United States</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, Melissa H.</creatorcontrib><creatorcontrib>Duh, Mei Sheng</creatorcontrib><creatorcontrib>Rothnie, Kieran J.</creatorcontrib><creatorcontrib>Zhang, Shiyuan</creatorcontrib><creatorcontrib>Czira, Alexandrosz</creatorcontrib><creatorcontrib>Slade, David</creatorcontrib><creatorcontrib>Cheng, Wendy Y.</creatorcontrib><creatorcontrib>Thompson-Leduc, Philippe</creatorcontrib><creatorcontrib>Greatsinger, Alexandra</creatorcontrib><creatorcontrib>Zhang, Adina</creatorcontrib><creatorcontrib>Mapel, Douglas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, Melissa H.</au><au>Duh, Mei Sheng</au><au>Rothnie, Kieran J.</au><au>Zhang, Shiyuan</au><au>Czira, Alexandrosz</au><au>Slade, David</au><au>Cheng, Wendy Y.</au><au>Thompson-Leduc, Philippe</au><au>Greatsinger, Alexandra</au><au>Zhang, Adina</au><au>Mapel, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2024-05</date><risdate>2024</risdate><volume>226</volume><spage>107630</spage><pages>107630-</pages><artnum>107630</artnum><issn>0954-6111</issn><issn>1532-3064</issn><eissn>1532-3064</eissn><abstract>Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed.
A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescription claim for inhaled corticosteroid/long-acting β2-agonist, and ≥1 medical claim with a diagnosis code for asthma was conducted. The objective was to refine current algorithms to identify moderate exacerbations in claims data and assess the refined algorithm's performance. Positive and negative predictive values (PPV and NPV) were assessed via chart review of 150 moderate exacerbations events and 50 patients without exacerbations. Sensitivity analyses assessed alternative algorithms and compared healthcare resource utilization (HRU) between algorithm-identified patients (claims group) and those confirmed by chart review (confirmed group) to have experienced a moderate exacerbation.
Algorithm-identified moderate exacerbations were: visit of ≤1 day with an asthma exacerbation diagnosis OR visit of ≤1 day with selected asthma diagnoses AND ≥1 respiratory pharmacy claim, excluding systemic corticosteroids, within 14 days after the first claim. The algorithm's PPV was 42%; the NPV was 78%. HRU was similar for both groups.
This algorithm identified potential moderate exacerbations from claims data; however, the modest PPV underscores its limitations in identifying moderate exacerbations, although performance was partially due to identification of previously unidentified severe exacerbations. Application of this algorithm in future claims-based studies may help quantify the economic burden of moderate and severe exacerbations in asthma when an algorithm identifying severe exacerbations is applied first.
•Definitions of moderate asthma exacerbation have been inconsistent (68/85 characters incl. spaces).•An algorithm was refined to identify moderate exacerbations in claims data (76/85 characters incl. spaces).•The algorithm may help quantify economic burden of moderate exacerbations in asthma (85/85 characters incl. spaces).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38593886</pmid><doi>10.1016/j.rmed.2024.107630</doi><orcidid>https://orcid.org/0000-0001-7451-7756</orcidid><orcidid>https://orcid.org/0000-0001-5035-6687</orcidid><orcidid>https://orcid.org/0000-0003-4279-1624</orcidid><orcidid>https://orcid.org/0000-0001-9047-3941</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0954-6111 |
ispartof | Respiratory medicine, 2024-05, Vol.226, p.107630, Article 107630 |
issn | 0954-6111 1532-3064 1532-3064 |
language | eng |
recordid | cdi_proquest_miscellaneous_3035539228 |
source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
subjects | Administration, Inhalation Adolescent Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Adrenergic beta-2 Receptor Agonists - administration & dosage Adrenergic beta-2 Receptor Agonists - therapeutic use Adult Aged Algorithms Asthma - diagnosis Asthma - drug therapy Asthma - economics Cohort Studies Disease Progression Female Healthcare economics Healthcare resource utilization (max. 6) Humans Insurance Claim Review Male Middle Aged Moderate exacerbations Retrospective Studies United States Young Adult |
title | Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A05%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20and%20validation%20of%20a%20claims-based%20algorithm%20to%20identify%20moderate%20exacerbations%20in%20patients%20with%20asthma%20treated%20in%20the%20US&rft.jtitle=Respiratory%20medicine&rft.au=Roberts,%20Melissa%20H.&rft.date=2024-05&rft.volume=226&rft.spage=107630&rft.pages=107630-&rft.artnum=107630&rft.issn=0954-6111&rft.eissn=1532-3064&rft_id=info:doi/10.1016/j.rmed.2024.107630&rft_dat=%3Cproquest_cross%3E3035539228%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c307t-fdfc7e0774fc7fa8da6135a5694fd41edf14c24e7d4195871c69b2806a0155a73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3035539228&rft_id=info:pmid/38593886&rfr_iscdi=true |