The Unseen Danger of Methotrexate Toxicity

Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, which is closely monitored by healthcare providers for its adverse effects. As a result, methotrexate toxicity occurs infrequently. We present a case of a 51-year-old woman with a past medical history of rheumatoid arthr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of community hospital internal medicine perspectives 2023, Vol.13 (6), p.39-42
Main Authors: Javed, Khalid, Wijeratne, Rashmi, Bandaru, Sumanth K
Format: Report
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 42
container_issue 6
container_start_page 39
container_title Journal of community hospital internal medicine perspectives
container_volume 13
creator Javed, Khalid
Wijeratne, Rashmi
Bandaru, Sumanth K
description Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, which is closely monitored by healthcare providers for its adverse effects. As a result, methotrexate toxicity occurs infrequently. We present a case of a 51-year-old woman with a past medical history of rheumatoid arthritis on methotrexate and prednisone. She presented to the emergency room with altered mental status, jaundice, and mucosal ulceration. She was subsequently admitted to the intensive care unit for septic shock in the setting of severe pancytopenia, acute renal failure and acute liver failure. This case demonstrates the importance of recognizing the signs and symptoms of methotrexate toxicity due to its infrequent presentation.
doi_str_mv 10.55729/2000-9666.1255
format report
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_3035540864</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3035540864</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_30355408643</originalsourceid><addsrcrecordid>eNqVij0LwjAURYMoWLSza0YRWl-TJrWzH7i4xbmE8morNdEmhfrvdRBxdbrnHC4hiwRiITKWrxkARLmUMk6YECMSfMP4h6ckdO76NpAsS4EHZKVqpGfjEA3daXPBjtqKntDX1nc4aI9U2aEpG_-ck0mlW4fhZ2dkedir7TG6d_bRo_PFrXEltq02aHtXcOBCpLCRKf_j-gIChDs2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype><pqid>3035540864</pqid></control><display><type>report</type><title>The Unseen Danger of Methotrexate Toxicity</title><source>Open Access: PubMed Central</source><creator>Javed, Khalid ; Wijeratne, Rashmi ; Bandaru, Sumanth K</creator><creatorcontrib>Javed, Khalid ; Wijeratne, Rashmi ; Bandaru, Sumanth K</creatorcontrib><description>Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, which is closely monitored by healthcare providers for its adverse effects. As a result, methotrexate toxicity occurs infrequently. We present a case of a 51-year-old woman with a past medical history of rheumatoid arthritis on methotrexate and prednisone. She presented to the emergency room with altered mental status, jaundice, and mucosal ulceration. She was subsequently admitted to the intensive care unit for septic shock in the setting of severe pancytopenia, acute renal failure and acute liver failure. This case demonstrates the importance of recognizing the signs and symptoms of methotrexate toxicity due to its infrequent presentation.</description><identifier>ISSN: 2000-9666</identifier><identifier>EISSN: 2000-9666</identifier><identifier>DOI: 10.55729/2000-9666.1255</identifier><language>eng</language><ispartof>Journal of community hospital internal medicine perspectives, 2023, Vol.13 (6), p.39-42</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>777,781,4476,27906</link.rule.ids></links><search><creatorcontrib>Javed, Khalid</creatorcontrib><creatorcontrib>Wijeratne, Rashmi</creatorcontrib><creatorcontrib>Bandaru, Sumanth K</creatorcontrib><title>The Unseen Danger of Methotrexate Toxicity</title><title>Journal of community hospital internal medicine perspectives</title><description>Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, which is closely monitored by healthcare providers for its adverse effects. As a result, methotrexate toxicity occurs infrequently. We present a case of a 51-year-old woman with a past medical history of rheumatoid arthritis on methotrexate and prednisone. She presented to the emergency room with altered mental status, jaundice, and mucosal ulceration. She was subsequently admitted to the intensive care unit for septic shock in the setting of severe pancytopenia, acute renal failure and acute liver failure. This case demonstrates the importance of recognizing the signs and symptoms of methotrexate toxicity due to its infrequent presentation.</description><issn>2000-9666</issn><issn>2000-9666</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2023</creationdate><recordtype>report</recordtype><recordid>eNqVij0LwjAURYMoWLSza0YRWl-TJrWzH7i4xbmE8morNdEmhfrvdRBxdbrnHC4hiwRiITKWrxkARLmUMk6YECMSfMP4h6ckdO76NpAsS4EHZKVqpGfjEA3daXPBjtqKntDX1nc4aI9U2aEpG_-ck0mlW4fhZ2dkedir7TG6d_bRo_PFrXEltq02aHtXcOBCpLCRKf_j-gIChDs2</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Javed, Khalid</creator><creator>Wijeratne, Rashmi</creator><creator>Bandaru, Sumanth K</creator><scope>7X8</scope></search><sort><creationdate>20230101</creationdate><title>The Unseen Danger of Methotrexate Toxicity</title><author>Javed, Khalid ; Wijeratne, Rashmi ; Bandaru, Sumanth K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_30355408643</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Javed, Khalid</creatorcontrib><creatorcontrib>Wijeratne, Rashmi</creatorcontrib><creatorcontrib>Bandaru, Sumanth K</creatorcontrib><collection>MEDLINE - Academic</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Javed, Khalid</au><au>Wijeratne, Rashmi</au><au>Bandaru, Sumanth K</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>The Unseen Danger of Methotrexate Toxicity</atitle><jtitle>Journal of community hospital internal medicine perspectives</jtitle><date>2023-01-01</date><risdate>2023</risdate><volume>13</volume><issue>6</issue><spage>39</spage><epage>42</epage><pages>39-42</pages><issn>2000-9666</issn><eissn>2000-9666</eissn><abstract>Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, which is closely monitored by healthcare providers for its adverse effects. As a result, methotrexate toxicity occurs infrequently. We present a case of a 51-year-old woman with a past medical history of rheumatoid arthritis on methotrexate and prednisone. She presented to the emergency room with altered mental status, jaundice, and mucosal ulceration. She was subsequently admitted to the intensive care unit for septic shock in the setting of severe pancytopenia, acute renal failure and acute liver failure. This case demonstrates the importance of recognizing the signs and symptoms of methotrexate toxicity due to its infrequent presentation.</abstract><doi>10.55729/2000-9666.1255</doi></addata></record>
fulltext fulltext
identifier ISSN: 2000-9666
ispartof Journal of community hospital internal medicine perspectives, 2023, Vol.13 (6), p.39-42
issn 2000-9666
2000-9666
language eng
recordid cdi_proquest_miscellaneous_3035540864
source Open Access: PubMed Central
title The Unseen Danger of Methotrexate Toxicity
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A42%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.atitle=The%20Unseen%20Danger%20of%20Methotrexate%20Toxicity&rft.jtitle=Journal%20of%20community%20hospital%20internal%20medicine%20perspectives&rft.au=Javed,%20Khalid&rft.date=2023-01-01&rft.volume=13&rft.issue=6&rft.spage=39&rft.epage=42&rft.pages=39-42&rft.issn=2000-9666&rft.eissn=2000-9666&rft_id=info:doi/10.55729/2000-9666.1255&rft_dat=%3Cproquest%3E3035540864%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_30355408643%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3035540864&rft_id=info:pmid/&rfr_iscdi=true