Assessing paraspinal muscle atrophy with electrical impedance myography: Limitations and insights

• Published in: Journal of orthopaedic research 2024-09, Vol.42 (9), p.2072-2079
• Main Authors: Guven, Ali E., Chiapparelli, Erika, Camino‐Willhuber, Gaston, Zhu, Jiaqi, Schönnagel, Lukas, Amoroso, Krizia, Caffard, Thomas, Erduran, Ada, Shue, Jennifer, Sama, Andrew A., Girardi, Federico P., Cammisa, Frank P., Hughes, Alexander P.
• Format: Article
• Language: English
• Subjects: Aged; Electric Impedance; electrical impedance myography; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; muscle quality assessment; Muscular Atrophy - diagnostic imaging; Myography; paraspinal muscle atrophy; Paraspinal Muscles - diagnostic imaging; Paraspinal Muscles - pathology; Paraspinal Muscles - physiopathology; Retrospective Studies; skin ultrasound; spinal sarcopenia; Ultrasonography
• ISSN: 0736-0266; 1554-527X; 1554-527X
• DOI: 10.1002/jor.25848

Paraspinal muscle atrophy is gaining attention in spine surgery due to its link to back pain, spinal degeneration and worse postoperative outcomes. Electrical impedance myography (EIM) is a noninvasive diagnostic tool for muscle quality assessment, primarily utilized for patients with neuromuscular diseases. However, EIM's accuracy for paraspinal muscle assessment remains understudied. In this study, we investigated the correlation between EIM readings and MRI‐derived muscle parameters, as well as the influence of dermal and subcutaneous parameters on these readings. We retrospectively analyzed patients with lumbar spinal degeneration who underwent paraspinal EIM assessment between May 2023 to July 2023. Paraspinal muscle fatty infiltration (FI) and functional cross‐sectional area (fCSA), as well as the subcutaneous thickness were assessed on MRI scans. Skin ultrasound imaging was assessed for dermal thickness and the echogenicities of the dermal and subcutaneous layers. All measurements were performed on the bilaterally. The correlation between EIM readings were compared with ultrasound and MRI parameters using Spearman's correlation analyses. A total of 20 patients (65.0% female) with a median age of 69.5 years (IQR, 61.3–73.8) were analyzed. The fCSA and FI did not significantly correlate with the EIM readings, regardless of frequency. All EIM readings across frequencies correlated with subcutaneous thickness, echogenicity, or dermal thickness. With the current methodology, paraspinal EIM is not a valid alternative to MRI assessment of muscle quality, as it is strongly influenced by the dermal and subcutaneous layers. Further studies are required for refining the methodology and confirming our results.