The level of cytokines in tears as a novel indicator of demyelinating diseases

A novel research objective is to identify new molecules in more readily accessible biological fluids that could be used in the diagnosis of multiple sclerosis (MS) and other demyelinating disorders. To compare the level of selected cytokines in tears between patients with MS or other demyelinating d...

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Bibliographic Details
Published in:Neurological research (New York) 2024-06, Vol.46 (6), p.1-494
Main Authors: Adamczyk-Zostawa, Jowita, Wylęgała, Adam, Lis, Martyna, Zostawa, Jacek, Fiolka, Rafał, Wylęgała, Edward, Adamczyk-Sowa, Monika, Czuba, Zenon
Format: Article
Language:English
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Summary:A novel research objective is to identify new molecules in more readily accessible biological fluids that could be used in the diagnosis of multiple sclerosis (MS) and other demyelinating disorders. To compare the level of selected cytokines in tears between patients with MS or other demyelinating disorder and healthy controls. 84 patients with diagnosed MS during remission or with other demyelinating disease of the CNS and 70 healthy controls were enrolled in the study. Tears were collected without any stimulation and stored till the day of assessment. The concentration of selected cytokines was measured by the Bio-Plex Pro Human cytokine screening panel 27 cytokines assay according to the manufacturer's instructions. Statistical analysis was performed with Statistica 13. IL-1b level was significantly lower in the study group compared to the control group [3,6 vs 8.71,  
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.2024.2337502