Erectile function preservation after radiotherapy using a dose-optimization approach on sexual structures for localized prostate cancer

Erectile function preservation is an important quality of life factor in patients treated for prostate cancer. A dose-optimization approach on sexual structures was developed and evaluated to limit erectile dysfunction after radiotherapy. Twenty-three men with localized prostate cancer and no erecti...

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Bibliographic Details
Published in:Cancer radiothérapie 2024-04, Vol.28 (2), p.182-187
Main Authors: Chardon, A., Udrescu, C., Beneux, A., Ruffion, A., Horn, S., Lapierre, A., Chapet, O.
Format: Article
Language:English
Subjects:
Cancer
Dose
Dose optimization
Erectile function
Fonction érectile
IRM
Magnetic resonance imaging
Optimisation
Prostate
Prostate cancer
Radiotherapy
Radiothérapie
Sexual structures
Structures sexuelles
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Summary:Erectile function preservation is an important quality of life factor in patients treated for prostate cancer. A dose-optimization approach on sexual structures was developed and evaluated to limit erectile dysfunction after radiotherapy. Twenty-three men with localized prostate cancer and no erectile dysfunction were enrolled in the study. All patients received a prescription dose between 76 and 78Gy. Computed tomography/magnetic resonance image registration was used to delineate the prostatic volume and the sexual structures: internal pudendal arteries (IPA), penile bulb and corpus cavernosum. Erectile function was evaluated using the 5-items International Index of Erectile Function (IIEF-5) score every 6 months during the 2 years after radiotherapy and once a year afterwards. No erectile dysfunction, mild erectile dysfunction and severe erectile dysfunction were defined if the IIEF-5 scores were 20–25, 17–19 and
ISSN:1278-3218
1769-6658
DOI:10.1016/j.canrad.2023.08.010