Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opa...

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Bibliographic Details
Published in:Internal medicine (Tokyo, 1992) 1992), 2024-12, Vol.63 (23), p.3227-3231
Main Authors: Nakamura, Satoshi, Takano, Tomotsugu, Nakatsuru, Kousei, Tsubouchi, Kazuya, Yamauchi, Takuji, Hashisako, Mikiko, Iwasaki, Takeshi, Okamoto, Isamu
Format: Article
Language:English
Subjects:
Aged
Biopsy
Case Report
Female
Humans
Lung diseases
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - immunology
Lymph nodes
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymphoma
Lymphoma, Follicular - complications
Lymphoma, Follicular - diagnosis
Lymphoma, Follicular - pathology
Male
Middle Aged
Pneumonia
T Follicular Helper Cells - immunology
Tomography, X-Ray Computed
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Summary:Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.3601-24