Drug-induced Steatohepatitis Caused by Long-term Use of Topical Steroids for Atopic Dermatitis

Atopic dermatitis is common in children and often treated with topical corticosteroids (TCs). A boy in his late teens who had been using TCs for atopic dermatitis was diagnosed with liver damage during a health checkup. A medical examination revealed severe steatotic liver disease and elevated liver...

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Bibliographic Details
Published in:Internal medicine (Tokyo, 1992) 1992), 2024-12, Vol.63 (23), p.3165
Main Authors: Tamura, Yuki, Naganuma, Atsushi, Suzuki, Yuhei, Uehara, Sanae, Hoshino, Takashi, Hatanaka, Takeshi, Shibusawa, Nobuyuki, Uehara, Akihito, Ogawa, Akira, Kakizaki, Satoru, Uraoka, Toshio
Format: Article
Language:English
Subjects:
Administration, Topical
Adolescent
Adrenal Cortex Hormones - administration & dosage
Adrenal Cortex Hormones - adverse effects
Adrenal Cortex Hormones - therapeutic use
Atopic dermatitis
Chemical and Drug Induced Liver Injury - diagnosis
Chemical and Drug Induced Liver Injury - etiology
Corticosteroids
Dermatitis, Atopic - drug therapy
Fatty Liver - chemically induced
Humans
Liver diseases
Male
Steroid hormones
Time Factors
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Summary:Atopic dermatitis is common in children and often treated with topical corticosteroids (TCs). A boy in his late teens who had been using TCs for atopic dermatitis was diagnosed with liver damage during a health checkup. A medical examination revealed severe steatotic liver disease and elevated liver enzyme levels despite the absence of typical symptoms such as central obesity. After discontinuation of TCs, an improvement in liver enzyme levels was observed, leading to the diagnosis of drug-induced steatohepatitis. This case underscores the potential liver risks associated with prolonged TC use in children, highlighting the need for parental education.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.3439-23