Resveratrol-Loaded Polydimethylsiloxane-Silica Hybrid Materials: Synthesis, Characterization, and Antitumoral Activity

In this work, hybrid materials within the polydimethylsiloxane-silica (PDMS-SiO ) system, synthesized via the sol-gel method, were developed and characterized for their potential to incorporate and release the bioactive compound resveratrol (RES). RES was incorporated into the materials with a high...

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Bibliographic Details
Published in:Polymers 2024-04, Vol.16 (7), p.879
Main Authors: Viegas, Sofia, Marinheiro, Diogo, Bastos, Verónica, Daniel-da-Silva, Ana L, Vieira, Ricardo, Oliveira, Helena, Almeida, José Carlos, Ferreira, Bárbara J M L
Format: Article
Language:English
Subjects:
Aluminum
Amorphization
Analysis
Anticancer properties
Bioavailability
Biocompatibility
Biomedical materials
Bone cancer
Bones
Chemical synthesis
Dimethylpolysiloxane
Drug delivery systems
Ethanol
Evaporators
Fourier transforms
Identification and classification
Methods
Nitrogen
Osteoporosis
Polydimethylsiloxane
Properties
Resveratrol
Scanning electron microscopy
Silica
Silicon dioxide
Sol-gel processes
Spectrum analysis
Thermogravimetric analysis
Time lag
Tissue engineering
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Summary:In this work, hybrid materials within the polydimethylsiloxane-silica (PDMS-SiO ) system, synthesized via the sol-gel method, were developed and characterized for their potential to incorporate and release the bioactive compound resveratrol (RES). RES was incorporated into the materials with a high loading efficiency (>75%) using the rotary evaporator technique. This incorporation induced the amorphization of RES, resulting in enhanced solubility and release when compared to the free polyphenolic compound. The release profiles displayed pH dependence, exhibiting notably faster release at pH 5.2 compared to pH 7.4. The gradual release of RES over time demonstrated an initial time lag of approximately 4 h, being well described by the Weibull model. cytotoxicity studies were conducted on human osteosarcoma cells (MG-63), revealing a concentration-dependent decrease in cell viability for RES-loaded samples (for concentrations >50 µg mL ).
ISSN:2073-4360
2073-4360
DOI:10.3390/polym16070879