Association of Peri-Implant Keratinized Mucosa Width and Mucosal Thickness with Early Bone Loss: A Cross-Sectional Study

• Published in: Journal of clinical medicine 2024-04, Vol.13 (7), p.1936
• Main Authors: Tastan Eroglu, Zeynep, Ozkan Sen, Dilek, Oncu, Elif
• Format: Article
• Language: English
• Subjects: Care and treatment; Cross-sectional studies; Dental implants; Dentistry; Evaluation; Genotype & phenotype; Health aspects; Immunology; Implant dentures; MicroRNA; MicroRNAs; Patient outcomes; Patients; Physiological aspects; Tooth loss; Tumor necrosis factor-TNF
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm13071936

The objective of this study was to evaluate the effects of keratinized mucosa width (KMW) and mucosal thickness (MT) around dental implants on marginal bone loss (MBL). The evaluation was performed one year after loading by comparing clinical, radiographic, and biochemical parameters. The study included 87 implants in 87 patients undergoing regular follow-ups without hard or soft tissue augmentation one year after loading. Clinical measurements included plaque index (PI), gingival index (GI), bleeding on probing (BoP), probing depth (PD), KMW, and MT. MBL was assessed with periapical radiography. The peri-implant crevicular fluid (PICF) was analyzed for tumor necrosis factor-alpha (TNF-α), receptor activator of nuclear factor-kB ligand (RANKL), osteoprotegerin (OPG), and microRNA-27a. The MBL of implants with thin MT ( 0.05). No significant associations was found between KMW and MT with TNF-α, RANKL, OPG and RANKL/OPG ( > 0.05), with the exception of increased microRNA-27a levels in implants with KMW ≥ 2 mm ( < 0.05). Implants with a thick MT had a lower MBL. There may be an association between adequate KMW and high miRNA-27a levels. The relationship between MBL and miRNA-27a remains unclear.