Sensitization-Associated Symptoms and Neuropathic-like Features in Patients with Cervical Dystonia and Pain

This exploratory study evaluated the presence of sensitization-associated and neuropathic-like symptoms and identified their association with pressure sensitivity, pain, and disability in patients with cervical dystonia (CD). Thirty-one patients with CD (74.2% women, age: 61.2 years, SD 10.1) partic...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-04, Vol.13 (7), p.2134
Main Authors: de-la-Hoz-López, Diego, Cuadrado, María L, López-Valdés, Eva, García-Ramos, Rocío, Alonso-Frech, Fernando, Fernández-Revuelta, Ana, Fernández-de-Las-Peñas, César, Gómez-Mayordomo, Víctor
Format: Article
Language:English
Subjects:
Anxiety
Cervix diseases
Chronic pain
Consent
Development and progression
Diagnosis
Dystonia
Mental depression
Movement disorders
Muscle contraction
Patients
Questionnaires
Risk factors
Self report
Sleep
Variables
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Summary:This exploratory study evaluated the presence of sensitization-associated and neuropathic-like symptoms and identified their association with pressure sensitivity, pain, and disability in patients with cervical dystonia (CD). Thirty-one patients with CD (74.2% women, age: 61.2 years, SD 10.1) participated. Data collected included clinical variables, the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), the Central Sensitization Inventory (CSI), the Self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), the Hospital Anxiety and Depression Scale (HADS) and the Pittsburgh Sleep Quality Index (PSQI), as well as widespread pressure pain thresholds (PPTs). Patients with CD with pain ( = 20, 64.5%) showed higher scores on the TWSTRS disability subscale and the CSI ( < 0.001), and lower PPTs ( < 0.05). Fifteen patients (15/31, 48%) showed sensitization-associated symptoms (CSI ≥ 40), whereas five of the patients with pain (5/20, 25%) exhibited neuropathic-like symptoms (S-LANSS ≥ 12). The CSI and S-LANSS were positively associated with the TWSTRS, HADS-A and HADS-D, and negatively associated with PPTs. HADS-D and S-LANSS explained 72.5% of the variance of the CSI (r : 0.725), whereas CSI explained 42.3% of the variance of the S-LANSS (r : 0.423). Pain is an important source of disability in CD, and may be a consequence of different mechanisms, including sensitization.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13072134