The bioaccessibility and tolerability of marine-derived sources of magnesium and calcium

• Published in: Methods (San Diego, Calif.) Calif.), 2024-06, Vol.226, p.28-34
• Main Authors: Dowley, Alison, Long-Smith, Caitriona M., Demehin, Olusoji, Nolan, Yvonne, O'Connell, Shane, O'Gorman, Denise M.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological Availability; Calcium - chemistry; Calcium - metabolism; Dietary Supplements - analysis; Digestion; Double-Blind Method; Female; Humans; Magnesium - chemistry; Male; Middle Aged; Minerals; Seawater - chemistry; Seaweed - chemistry; Solubility
• ISSN: 1046-2023; 1095-9130
• DOI: 10.1016/j.ymeth.2024.04.009

•Magnesium and calcium deficiencies are prevalent worldwide.•Aquamin is rich in bioactive minerals like magnesium & calcium and 72 trace minerals.•This study compares Aquamin-Mg solubility with other magnesium supplements.•This study assesses Aquamin MMB's tolerability in healthy older adults. It is generally accepted that mineral deficiencies, including magnesium and calcium, are widespread globally. Dietary supplementation may be an effective approach to combat such deficiencies. However, challenges associated with limited mineral solubility in the digestive system can impede effective dissolution and hinder absorption, leading to deficiency, and undesirable gastrointestinal disturbances including diarrhoea. Seawater is considered to be a rich source of bioactive magnesium, calcium, and 72 other trace minerals. In this study, we examine two different marine-derived multimineral products as potential dietary supplements. Aquamin-Mg, sourced from seawater is rich in magnesium (12%), and Aquamin F, a seaweed-derived multimineral is rich in calcium (32%). Both products also contain a diverse array of over 72 minerals, characteristic of their oceanic origin. Our study comprises two experiments. The first experiment evaluates and compares the solubility of Aquamin-Mg, commercially available magnesium bisglycinate, and Pure Magnesium Bisglycinate (PrizMAG) during in vitro digestion using the INFOGEST method. Results demonstrate that Aquamin-Mg exhibits superior solubility than the other magnesium sources during the gastric and intestinal phases, particularly when administered alongside food materials. The second experiment is a randomized, double-blind, placebo-controlled study in a small cohort of healthy older aged adults to assess the tolerability of a combined Aquamin-Mg/Aquamin-F supplement over a 12-week period. The findings indicate that this combination supplement is well-tolerated, with no significant adverse events reported, emphasizing its potential as a means of addressing mineral deficiencies.