Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial

• Published in: Canadian journal of diabetes 2024-07, Vol.48 (5), p.330-336.e2
• Main Authors: Verbeeten, Kate C., Tang, Ken, Courtney, Jennilea M., Bradley, Brenda J., McAssey, Karen, Clarson, Cheril, Kirsch, Susan, Curtis, Jacqueline R., Mahmud, Farid H., Richardson, Christine, Cooper, Tammy, Lawson, Margaret L.
• Format: Article
• Language: English
• Subjects: Adolescent; Blood Glucose - analysis; Blood Glucose Self-Monitoring - methods; Child; Continuous Glucose Monitoring; contrôle glycémique; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; diabète de type 1; Female; fructosamine; Fructosamine - blood; Glycated Hemoglobin - analysis; Glycemic Control; glycemic management; Humans; Male; pediatrics; pédiatrie; surveillance continue du glucose; type 1 diabetes
• ISSN: 1499-2671; 2352-3840; 2352-3840
• DOI: 10.1016/j.jcjd.2024.04.007

Our aim in this study was to determine the correlation between serum fructosamine and average blood glucose, as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes. Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous glucose Monitoring in Established pediatric diabetes (CGM TIME) Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence before blood collection. Ordinary least-squares linear regression incorporating restricted cubic splines was used to determine the association between fructosamine levels and mean blood glucose. An association was found between fructosamine and mean blood glucose, with an F statistic of 9.543 (p