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Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial
Our aim in this study was to determine the correlation between serum fructosamine and average blood glucose, as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes. Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous g...
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| Published in: | Canadian journal of diabetes 2024-07, Vol.48 (5), p.330-336.e2 |
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| container_end_page | 336.e2 |
| container_issue | 5 |
| container_start_page | 330 |
| container_title | Canadian journal of diabetes |
| container_volume | 48 |
| creator | Verbeeten, Kate C. Tang, Ken Courtney, Jennilea M. Bradley, Brenda J. McAssey, Karen Clarson, Cheril Kirsch, Susan Curtis, Jacqueline R. Mahmud, Farid H. Richardson, Christine Cooper, Tammy Lawson, Margaret L. |
| description | Our aim in this study was to determine the correlation between serum fructosamine and average blood glucose, as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes.
Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous glucose Monitoring in Established pediatric diabetes (CGM TIME) Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence before blood collection. Ordinary least-squares linear regression incorporating restricted cubic splines was used to determine the association between fructosamine levels and mean blood glucose.
An association was found between fructosamine and mean blood glucose, with an F statistic of 9.543 (p |
| doi_str_mv | 10.1016/j.jcjd.2024.04.007 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3038444471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S149926712400073X</els_id><sourcerecordid>3038444471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c237t-fbfae5eccce6bc4b860ffc3bf24998823faf1111ba72e8c4656f8735fbdd8c6c3</originalsourceid><addsrcrecordid>eNp9kcGO0zAQhiMEYsvCC3BAc-SSYjtpkiIuq-xuWakVEiriaDmT8dZRYhfbWanvxEPiqgtHRiPNHL75Nfr_LHvP2ZIzXn0algMO_VIwUS5Zala_yBaiWIm8aEr2Mlvwcr3ORVXzq-xNCANjK1bz9evsqmgqXgpeLbLfNyE4NCoaZ8FpuPczRhfUZCzBlp5oDPDTxANsxhPSZBB2yqpHmshGMBbagxl7T_YC7U9HAg63RnUUKYAKcJsWf1broTtB62w0dnZzSIIzukCwc9ZE5419_AzfKcxjDOkLN0E8ELSbHewfdnew90aNb7NXWo2B3j3P6-zH_d2-_Zpvv20e2pttjqKoY647rWhFiEhVh2XXVExrLDotkh9NIwqtNE_VqVpQg2W1qnRTFyvd9X2DFRbX2ceL7tG7XzOFKCcTkMZRWUqvy4Ilg1PVPKHigqJ3IXjS8ujNpPxJcibPKclBnlOS55QkS83qdPThWX_uJur_nfyNJQFfLkCyn54MeRnQkEXqjSeMsnfmf_p_ADvAplI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3038444471</pqid></control><display><type>article</type><title>Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Verbeeten, Kate C. ; Tang, Ken ; Courtney, Jennilea M. ; Bradley, Brenda J. ; McAssey, Karen ; Clarson, Cheril ; Kirsch, Susan ; Curtis, Jacqueline R. ; Mahmud, Farid H. ; Richardson, Christine ; Cooper, Tammy ; Lawson, Margaret L.</creator><creatorcontrib>Verbeeten, Kate C. ; Tang, Ken ; Courtney, Jennilea M. ; Bradley, Brenda J. ; McAssey, Karen ; Clarson, Cheril ; Kirsch, Susan ; Curtis, Jacqueline R. ; Mahmud, Farid H. ; Richardson, Christine ; Cooper, Tammy ; Lawson, Margaret L. ; CGM TIME Trial Study Group ; JDRF Canadian Clinical Trials Group</creatorcontrib><description>Our aim in this study was to determine the correlation between serum fructosamine and average blood glucose, as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes.
Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous glucose Monitoring in Established pediatric diabetes (CGM TIME) Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence before blood collection. Ordinary least-squares linear regression incorporating restricted cubic splines was used to determine the association between fructosamine levels and mean blood glucose.
An association was found between fructosamine and mean blood glucose, with an F statistic of 9.543 (p<0.001). Data were used to create a formula and conversion chart for calculating mean blood glucose from fructosamine levels for clinical use.
There is a complex relationship between average blood glucose, as determined by CGM and fructosamine. Fructosamine levels may be clinically useful for assessing short-term glycemic management when CGM is not available.
Déterminer la corrélation entre la fructosamine sérique et la glycémie moyenne mesurée lors de la surveillance continue du glucose (SCG, ou CGM en anglais) chez les enfants atteints de diabète de type 1.
Quatre-vingt-dix-sept échantillons de sang ont été prélevés auprès de 70 participants de l'essai CGM TIME. Chaque participant éligible disposait de 3 semaines de données SCG avec une adhésion à la SCG d'au moins 60% avant le prélèvement sanguin. Une régression linéaire par la méthode des moindres carrés ordinaires intégrant des splines cubiques restreintes a été utilisée pour déterminer l'association entre les niveaux de fructosamine et la glycémie moyenne.
Une association a été trouvée entre la fructosamine et la glycémie moyenne, avec une statistique F de 9.543 (valeur de p <0.001). Les données ont été utilisées pour créer une formule et un tableau de conversion permettant de calculer la glycémie moyenne à partir des taux de fructosamine pour un usage clinique.
Il existe une relation complexe entre la glycémie moyenne déterminée par la SCG et la fructosamine. Les taux de fructosamine peuvent être utiles cliniquement pour évaluer le contrôle glycémique à court terme lorsque la SCG n'est pas disponible.</description><identifier>ISSN: 1499-2671</identifier><identifier>ISSN: 2352-3840</identifier><identifier>EISSN: 2352-3840</identifier><identifier>DOI: 10.1016/j.jcjd.2024.04.007</identifier><identifier>PMID: 38614216</identifier><language>eng</language><publisher>Canada: Elsevier Inc</publisher><subject>Adolescent ; Blood Glucose - analysis ; Blood Glucose Self-Monitoring - methods ; Child ; Continuous Glucose Monitoring ; contrôle glycémique ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; diabète de type 1 ; Female ; fructosamine ; Fructosamine - blood ; Glycated Hemoglobin - analysis ; Glycemic Control ; glycemic management ; Humans ; Male ; pediatrics ; pédiatrie ; surveillance continue du glucose ; type 1 diabetes</subject><ispartof>Canadian journal of diabetes, 2024-07, Vol.48 (5), p.330-336.e2</ispartof><rights>2024 Canadian Diabetes Association</rights><rights>Copyright © 2024 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c237t-fbfae5eccce6bc4b860ffc3bf24998823faf1111ba72e8c4656f8735fbdd8c6c3</cites><orcidid>0000-0001-9106-8737 ; 0000-0002-1446-7061</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38614216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verbeeten, Kate C.</creatorcontrib><creatorcontrib>Tang, Ken</creatorcontrib><creatorcontrib>Courtney, Jennilea M.</creatorcontrib><creatorcontrib>Bradley, Brenda J.</creatorcontrib><creatorcontrib>McAssey, Karen</creatorcontrib><creatorcontrib>Clarson, Cheril</creatorcontrib><creatorcontrib>Kirsch, Susan</creatorcontrib><creatorcontrib>Curtis, Jacqueline R.</creatorcontrib><creatorcontrib>Mahmud, Farid H.</creatorcontrib><creatorcontrib>Richardson, Christine</creatorcontrib><creatorcontrib>Cooper, Tammy</creatorcontrib><creatorcontrib>Lawson, Margaret L.</creatorcontrib><creatorcontrib>CGM TIME Trial Study Group</creatorcontrib><creatorcontrib>JDRF Canadian Clinical Trials Group</creatorcontrib><title>Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial</title><title>Canadian journal of diabetes</title><addtitle>Can J Diabetes</addtitle><description>Our aim in this study was to determine the correlation between serum fructosamine and average blood glucose, as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes.
Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous glucose Monitoring in Established pediatric diabetes (CGM TIME) Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence before blood collection. Ordinary least-squares linear regression incorporating restricted cubic splines was used to determine the association between fructosamine levels and mean blood glucose.
An association was found between fructosamine and mean blood glucose, with an F statistic of 9.543 (p<0.001). Data were used to create a formula and conversion chart for calculating mean blood glucose from fructosamine levels for clinical use.
There is a complex relationship between average blood glucose, as determined by CGM and fructosamine. Fructosamine levels may be clinically useful for assessing short-term glycemic management when CGM is not available.
Déterminer la corrélation entre la fructosamine sérique et la glycémie moyenne mesurée lors de la surveillance continue du glucose (SCG, ou CGM en anglais) chez les enfants atteints de diabète de type 1.
Quatre-vingt-dix-sept échantillons de sang ont été prélevés auprès de 70 participants de l'essai CGM TIME. Chaque participant éligible disposait de 3 semaines de données SCG avec une adhésion à la SCG d'au moins 60% avant le prélèvement sanguin. Une régression linéaire par la méthode des moindres carrés ordinaires intégrant des splines cubiques restreintes a été utilisée pour déterminer l'association entre les niveaux de fructosamine et la glycémie moyenne.
Une association a été trouvée entre la fructosamine et la glycémie moyenne, avec une statistique F de 9.543 (valeur de p <0.001). Les données ont été utilisées pour créer une formule et un tableau de conversion permettant de calculer la glycémie moyenne à partir des taux de fructosamine pour un usage clinique.
Il existe une relation complexe entre la glycémie moyenne déterminée par la SCG et la fructosamine. Les taux de fructosamine peuvent être utiles cliniquement pour évaluer le contrôle glycémique à court terme lorsque la SCG n'est pas disponible.</description><subject>Adolescent</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose Self-Monitoring - methods</subject><subject>Child</subject><subject>Continuous Glucose Monitoring</subject><subject>contrôle glycémique</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>diabète de type 1</subject><subject>Female</subject><subject>fructosamine</subject><subject>Fructosamine - blood</subject><subject>Glycated Hemoglobin - analysis</subject><subject>Glycemic Control</subject><subject>glycemic management</subject><subject>Humans</subject><subject>Male</subject><subject>pediatrics</subject><subject>pédiatrie</subject><subject>surveillance continue du glucose</subject><subject>type 1 diabetes</subject><issn>1499-2671</issn><issn>2352-3840</issn><issn>2352-3840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcGO0zAQhiMEYsvCC3BAc-SSYjtpkiIuq-xuWakVEiriaDmT8dZRYhfbWanvxEPiqgtHRiPNHL75Nfr_LHvP2ZIzXn0algMO_VIwUS5Zala_yBaiWIm8aEr2Mlvwcr3ORVXzq-xNCANjK1bz9evsqmgqXgpeLbLfNyE4NCoaZ8FpuPczRhfUZCzBlp5oDPDTxANsxhPSZBB2yqpHmshGMBbagxl7T_YC7U9HAg63RnUUKYAKcJsWf1broTtB62w0dnZzSIIzukCwc9ZE5419_AzfKcxjDOkLN0E8ELSbHewfdnew90aNb7NXWo2B3j3P6-zH_d2-_Zpvv20e2pttjqKoY647rWhFiEhVh2XXVExrLDotkh9NIwqtNE_VqVpQg2W1qnRTFyvd9X2DFRbX2ceL7tG7XzOFKCcTkMZRWUqvy4Ilg1PVPKHigqJ3IXjS8ujNpPxJcibPKclBnlOS55QkS83qdPThWX_uJur_nfyNJQFfLkCyn54MeRnQkEXqjSeMsnfmf_p_ADvAplI</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Verbeeten, Kate C.</creator><creator>Tang, Ken</creator><creator>Courtney, Jennilea M.</creator><creator>Bradley, Brenda J.</creator><creator>McAssey, Karen</creator><creator>Clarson, Cheril</creator><creator>Kirsch, Susan</creator><creator>Curtis, Jacqueline R.</creator><creator>Mahmud, Farid H.</creator><creator>Richardson, Christine</creator><creator>Cooper, Tammy</creator><creator>Lawson, Margaret L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9106-8737</orcidid><orcidid>https://orcid.org/0000-0002-1446-7061</orcidid></search><sort><creationdate>202407</creationdate><title>Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial</title><author>Verbeeten, Kate C. ; 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Ninety-seven blood samples were collected from 70 participants in the Timing of Initiation of continuous glucose Monitoring in Established pediatric diabetes (CGM TIME) Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence before blood collection. Ordinary least-squares linear regression incorporating restricted cubic splines was used to determine the association between fructosamine levels and mean blood glucose.
An association was found between fructosamine and mean blood glucose, with an F statistic of 9.543 (p<0.001). Data were used to create a formula and conversion chart for calculating mean blood glucose from fructosamine levels for clinical use.
There is a complex relationship between average blood glucose, as determined by CGM and fructosamine. Fructosamine levels may be clinically useful for assessing short-term glycemic management when CGM is not available.
Déterminer la corrélation entre la fructosamine sérique et la glycémie moyenne mesurée lors de la surveillance continue du glucose (SCG, ou CGM en anglais) chez les enfants atteints de diabète de type 1.
Quatre-vingt-dix-sept échantillons de sang ont été prélevés auprès de 70 participants de l'essai CGM TIME. Chaque participant éligible disposait de 3 semaines de données SCG avec une adhésion à la SCG d'au moins 60% avant le prélèvement sanguin. Une régression linéaire par la méthode des moindres carrés ordinaires intégrant des splines cubiques restreintes a été utilisée pour déterminer l'association entre les niveaux de fructosamine et la glycémie moyenne.
Une association a été trouvée entre la fructosamine et la glycémie moyenne, avec une statistique F de 9.543 (valeur de p <0.001). Les données ont été utilisées pour créer une formule et un tableau de conversion permettant de calculer la glycémie moyenne à partir des taux de fructosamine pour un usage clinique.
Il existe une relation complexe entre la glycémie moyenne déterminée par la SCG et la fructosamine. Les taux de fructosamine peuvent être utiles cliniquement pour évaluer le contrôle glycémique à court terme lorsque la SCG n'est pas disponible.</abstract><cop>Canada</cop><pub>Elsevier Inc</pub><pmid>38614216</pmid><doi>10.1016/j.jcjd.2024.04.007</doi><orcidid>https://orcid.org/0000-0001-9106-8737</orcidid><orcidid>https://orcid.org/0000-0002-1446-7061</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1499-2671 |
| ispartof | Canadian journal of diabetes, 2024-07, Vol.48 (5), p.330-336.e2 |
| issn | 1499-2671 2352-3840 2352-3840 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3038444471 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adolescent Blood Glucose - analysis Blood Glucose Self-Monitoring - methods Child Continuous Glucose Monitoring contrôle glycémique Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy diabète de type 1 Female fructosamine Fructosamine - blood Glycated Hemoglobin - analysis Glycemic Control glycemic management Humans Male pediatrics pédiatrie surveillance continue du glucose type 1 diabetes |
| title | Association of Fructosamine Levels With Glycemic Management in Children With Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results From the CGM TIME Trial |
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