Iron overload disorders: Growth and gonadal dysfunction in childhood and adolescence

Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body, resulting in organ damage. Endocrine complications are particularly common, especially when the condition manifests in childhood or adolescence, when HC can adversely affect linear growth or pubertal developme...

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Bibliographic Details
Published in:Pediatric blood & cancer 2024-07, Vol.71 (7), p.e30995-n/a
Main Authors: Tenuta, Marta, Cangiano, Biagio, Rastrelli, Giulia, Carlomagno, Francesco, Sciarra, Francesca, Sansone, Andrea, Isidori, Andrea M., Gianfrilli, Daniele, Krausz, Csilla
Format: Article
Language:English
Subjects:
Adolescents
Children
delayed puberty
Diagnosis
growth hormone deficiency
Hemochromatosis
iron overload disease
linear growth
Precision medicine
pubertal development
Puberty
Quality of life
thalassemia
transfusions
transition age
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Summary:Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body, resulting in organ damage. Endocrine complications are particularly common, especially when the condition manifests in childhood or adolescence, when HC can adversely affect linear growth or pubertal development, with significant repercussions on quality of life even into adulthood. Therefore, a timely and accurate diagnosis of these disorders is mandatory, but sometimes complex for hematologists without endocrinological support. This is a narrative review focused on puberty and growth disorders during infancy and adolescence aiming to offer guidance for diagnosis, treatment, and proper follow‐up. Additionally, it aims to highlight gaps in the existing literature and emphasizes the importance of collaboration among specialists, which is essential in the era of precision medicine.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.30995