Impact of optimal cholesterol levels on subclinical atherosclerosis in the absence of risk factors in young adults

We aimed to assess the association of blood lipids with the prevalence, incidence, and progression of subclinical atherosclerosis among young individuals without dyslipidemia and other traditional cardiovascular risk factors (CVRFs). A total of 1270 participants from the Coronary Artery Risk Develop...

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Bibliographic Details
Published in:Atherosclerosis 2024-06, Vol.393, p.117520, Article 117520
Main Authors: Masrouri, Soroush, Tamehri Zadeh, Seyed Saeed, Shapiro, Michael D., Khalili, Davood, Hadaegh, Farzad
Format: Article
Language:English
Subjects:
Adult
Age Factors
Arteriopathy
Asymptomatic Diseases
Atherosclerosis - blood
Atherosclerosis - diagnosis
Atherosclerosis - epidemiology
Biomarkers - blood
CARDIA study
Carotid Artery Diseases - blood
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Carotid Intima-Media Thickness
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary artery calcification progression
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Disease Progression
Female
Heart Disease Risk Factors
Humans
Incidence
Male
Middle Aged
Prevalence
Risk Assessment
Risk Factors
Subclinical atherosclerosis
Triglycerides - blood
United States - epidemiology
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Summary:We aimed to assess the association of blood lipids with the prevalence, incidence, and progression of subclinical atherosclerosis among young individuals without dyslipidemia and other traditional cardiovascular risk factors (CVRFs). A total of 1270 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study aged 32–46 years free of cardiovascular disease, diabetes, hypertension, current smoking, and dyslipidemia (total cholesterol [TC] ≥ 240 mg/dL, triglycerides [TG] ≥ 150 mg/dL, low-density lipoprotein cholesterol [LDL-C] ≥ 160 mg/dL, high-density lipoprotein cholesterol [HDL-C] 
ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2024.117520