Harnessing gastrointestinal organoids for cancer therapy

Gastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cance...

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Bibliographic Details
Published in:Trends in molecular medicine 2024-07, Vol.30 (7), p.617-619
Main Authors: Maubach, Gunter, Naumann, Michael
Format: Article
Language:English
Subjects:
Animals
cancer modeling
carcinogenic pathogens
Drug Discovery - methods
drug sensitivity testing
Gastrointestinal Tract - pathology
Humans
mucosoids
Neoplasms - pathology
Neoplasms - therapy
Organoids - pathology
patient-derived organoids
Pluripotent Stem Cells - cytology
precision medicine
Citations: Items that this one cites
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Summary:Gastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens. Gastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.
ISSN:1471-4914
1471-499X
1471-499X
DOI:10.1016/j.molmed.2024.03.010