Accessing pyrrolo[1,2- a ]indole derivatives via visible-light-induced dearomatizative cyclization of indoles

Pyrrolo[1,2- ]indoles are structurally important scaffolds in many natural products and bioactive compounds. Herein, we report a novel synthetic method for pyrrolo[1,2- ]indole derivatives through visible-light-induced cascade dearomatizative cyclization of indoles with external nucleophiles. Modera...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-05, Vol.60 (37), p.4902-4905
Main Authors: Liu, Zhaosheng, Ji, Xiaochen, Duan, Lilan, Deng, Guo-Jun, Huang, Huawen
Format: Article
Language:English
Subjects:
Indoles
Natural products
Nucleophiles
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Summary:Pyrrolo[1,2- ]indoles are structurally important scaffolds in many natural products and bioactive compounds. Herein, we report a novel synthetic method for pyrrolo[1,2- ]indole derivatives through visible-light-induced cascade dearomatizative cyclization of indoles with external nucleophiles. Moderate yields, good diastereoselectivities, and excellent regioselectivities were generally observed with the resultant indole-fused polycyclic compounds.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc01215a