MucR protein: Three decades of studies have led to the identification of a new H-NS-like protein

• Published in: Molecular microbiology 2024-04
• Main Authors: Baglivo, Ilaria, Malgieri, Gaetano, Roop, 2nd, Roy Martin, Barton, Ian S, Wang, Xindan, Russo, Veronica, Pirone, Luciano, Pedone, Emilia M, Pedone, Paolo V
• Format: Article
• Language: English
• ISSN: 0950-382X; 1365-2958; 1365-2958
• DOI: 10.1111/mmi.15261

MucR belongs to a large protein family whose members regulate the expression of virulence and symbiosis genes in α-proteobacteria species. This protein and its homologs were initially studied as classical transcriptional regulators mostly involved in repression of target genes by binding their promoters. Very recent studies have led to the classification of MucR as a new type of Histone-like Nucleoid Structuring (H-NS) protein. Thus this review is an effort to put together a complete and unifying story demonstrating how genetic and biochemical findings on MucR suggested that this protein is not a classical transcriptional regulator, but functions as a novel type of H-NS-like protein, which binds AT-rich regions of genomic DNA and regulates gene expression.