Promoter of lncRNA MORT is aberrantly methylated in colorectal cancer

Aberrant DNA methylation plays essential roles in the colorectal cancer (CRC) carcinogenesis and has been demonstrated as a promising marker for cancer early detection. In this project, methylation status of the promoter was studied in CRC and their marginal tissues using qMSP assay. Furthermore, we...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2024-04, p.1-13
Main Authors: Nazari, Aylar, Ghasemi, Tayyebeh, Khalaj-Kondori, Mohammad, Fathi, Ramin
Format: Article
Language:English
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Summary:Aberrant DNA methylation plays essential roles in the colorectal cancer (CRC) carcinogenesis and has been demonstrated as a promising marker for cancer early detection. In this project, methylation status of the promoter was studied in CRC and their marginal tissues using qMSP assay. Furthermore, we investigated the molecular function of in CRC progression using computational analysis. The results showed a high methylation level of promoter in CRC tissues. By in silico analysis, we found that downregulation could promote the proliferation of CRC cells sponging of and , and alteration of their targets expression pattern such as and . In conclusion, based on our results, promoter hypermethylation of MORT might be considered as a potential biomarker for CRC detection.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770.2024.2328732