Identification of Irpex and Rhodotorula on surveillance bronchoscopy in a pediatric lung transplant recipient: A case report and review of literature of these atypical fungal organisms

• Published in: Pediatric transplantation 2024-05, Vol.28 (3), p.e14759-n/a
• Main Authors: Atwood, Daniel T., Köhler, Julia R., Vargas, Sara O., Wong, Wai, Klouda, Timothy
• Format: Article
• Language: English
• Subjects: Adolescent; Antifungal Agents - therapeutic use; atypical fungi; Biopsy; Bronchitis; Bronchoscopy; Case reports; Child; Conidia; Female; Humans; Immunocompromised hosts; Immunosuppressive agents; Invasive Fungal Infections; Irpex lacteus; Lung; lung transplant; Lung transplantation; Lung Transplantation - adverse effects; Lung transplants; Pathogenicity; pediatric; Pediatrics; Polyporales; Rhodotorula; Risk factors; Surveillance; Transplant Recipients
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/petr.14759

Background Invasive fungal disease (IFD) is a frequent complication in pediatric lung transplant recipients, occurring in up to 12% of patients in the first year. Risk factors for infection include impaired lung defenses and intense immunosuppressive regimens. While most IFD occurs from Aspergillus, other fungal conidia are continuously inhaled, and infections with fungi on a spectrum of human pathogenicity can occur. Case Report We report a case of a 17‐year‐old lung transplant recipient in whom Irpex lacteus and Rhodotorula species were identified during surveillance bronchoscopy. She was asymptomatic and deemed to be colonized by Irpex lacteus and Rhodotorula species following transplant. 2 years after transplantation, she developed a fever, respiratory symptoms, abnormal lung imaging, and histological evidence of acute and chronic bronchitis on transbronchial biopsy. After developing symptoms concerning for a pulmonary infection and graft dysfunction, she was treated for a presumed IFD. Unfortunately, further diagnostic testing could not be performed at this time given her tenuous clinical status. Despite the initiation of antifungal therapy, her graft function continued to decline resulting in a second lung transplantation. Conclusions This case raises the concern for IFD in lung transplant recipients from Irpex species. Further investigation is needed to understand the pathogenicity of this organism, reduce the incidence and mortality of IFD in lung transplant recipients, and refine the approach to diagnosis and manage the colonization and isolation of rare, atypical fungal pathogens in immunocompromised hosts.