Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects

Nucleic acids (NAs) are important components of living organisms responsible for the storage and transmission of hereditary information. They form complex structures that can self-assemble and bind to various biological molecules. DNAzymes are NAs capable of performing simple chemical reactions, whi...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2024, Vol.89 (Suppl 1), p.S249-S261
Main Authors: Nedorezova, Daria D., Rubel, Maria S., Rubel, Aleksandr A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Biosensing Techniques
Chemical reactions
Deoxyribonucleic acid
Deoxyribozymes
DNA
DNA - metabolism
DNA, Catalytic - chemistry
DNA, Catalytic - genetics
DNA, Catalytic - metabolism
Enzymes
Life Sciences
Medical treatment
Microbiology
Molecular biology
Molecular structure
New technology
Nucleic acids
Review
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Summary:Nucleic acids (NAs) are important components of living organisms responsible for the storage and transmission of hereditary information. They form complex structures that can self-assemble and bind to various biological molecules. DNAzymes are NAs capable of performing simple chemical reactions, which makes them potentially useful elements for creating DNA nanomachines with required functions. This review focuses on multicomponent DNA-based nanomachines, in particular on DNAzymes as their main functional elements, as well as on the structure of DNAzyme nanomachines and their application in the diagnostics and treatment of diseases. The article also discusses the advantages and disadvantages of DNAzyme-based nanomachines and prospects for their future applications. The review provides information about new technologies and the possibilities of using NAs in medicine.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297924140141